Iida T, Hagimura N, Kishi S, Shimizu K
Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Japan.
Am J Ophthalmol. 1998 Jul;126(1):70-6. doi: 10.1016/s0002-9394(98)00167-6.
To clarify the indocyanine green angiographic features of idiopathic submacular choroidal neovascularization.
We performed fluorescein and indocyanine green angiography in 16 eyes of 16 patients (nine men, seven women; mean age +/- SD, 35.6 +/- 6.9 years; range, 24 to 48 years) with idiopathic submacular choroidal neovascularization. During the mean follow-up of 11.4 +/- 7.9 months (range, 1 to 28 months), angiography was repeated (mean, 2.6 +/- 0.5 times; range, 2 to 3 times) in 12 eyes and performed only once in four eyes.
In the early phase of indocyanine green angiography, a network of choroidal neovascularization was observed in 11 of the 16 eyes with well-defined choroidal neovascularization seen by fluorescein angiography. Choroidal hyperfluorescent areas were noted in 10 of the 16 eyes in the late-phase angiography. Three of the 10 eyes showed focal dilatation of choroidal veins within the hyperfluorescent areas. Choroidal neovascular membrane was located within the hyperfluorescent areas in eight of the 10 eyes with choroidal hyperfluorescent areas. A dark rim surrounding choroidal neovascularization was observed in 13 of the 16 eyes at the initial examination. Indocyanine green angiography was repeated in nine of the 13 eyes and in the other three eyes without dark rim initially. During the follow-up period, the dark rim became prominent in eight of the nine eyes and developed in one eye without dark rim initially. Choroidal neovascular membrane regressed in these nine eyes. Choroidal neovascularization remained active or enlarged in three eyes in which the dark rim was stationary or invisible.
The dark rim surrounding the choroidal neovascularization in indocyanine green angiograms appeared to reflect regression of idiopathic choroidal neovascularization. Choroidal vascular abnormalities such as hyperfluorescent areas or focal venous dilatation seem to be the background lesion predisposing to the choroidal neovascularization.
阐明特发性黄斑下脉络膜新生血管的吲哚青绿血管造影特征。
我们对16例（9例男性，7例女性；平均年龄±标准差，35.6±6.9岁；范围，24至48岁）特发性黄斑下脉络膜新生血管患者的16只眼进行了荧光素和吲哚青绿血管造影。在平均11.4±7.9个月（范围，1至28个月）的随访期间，12只眼重复进行了血管造影（平均，2.6±0.5次；范围，2至3次），4只眼仅进行了一次。
在吲哚青绿血管造影的早期阶段，16只眼中有11只观察到脉络膜新生血管网络，荧光素血管造影可见明确的脉络膜新生血管。在晚期血管造影中，16只眼中有10只出现脉络膜高荧光区。10只眼中有3只在高荧光区内显示脉络膜静脉局灶性扩张。10只出现脉络膜高荧光区的眼中有8只脉络膜新生血管膜位于高荧光区内。在初次检查时，16只眼中有13只观察到脉络膜新生血管周围有暗边。13只眼中有9只以及最初没有暗边的另外3只眼重复进行了吲哚青绿血管造影。在随访期间，9只眼中有8只暗边变得明显，1只最初没有暗边的眼出现了暗边。这9只眼中脉络膜新生血管膜消退。在3只眼中，暗边静止或不可见，脉络膜新生血管保持活跃或扩大。
吲哚青绿血管造影中脉络膜新生血管周围的暗边似乎反映了特发性脉络膜新生血管的消退。脉络膜血管异常，如高荧光区或局灶性静脉扩张，似乎是脉络膜新生血管形成的背景病变。
