Nevalainen T J, Haapanen T J, Rajala P, Ekfors T
Department of Pathology, University of Turku, Finland.
APMIS. 1998 Aug;106(8):780-4. doi: 10.1111/j.1699-0463.1998.tb00224.x.
A case of tubulovillous adenoma in the rectum of a 51-year-old man is presented. The tumour contained numerous Paneth cells which formed well-developed glands in the basal areas. Group II phospholipase A2 and lysozyme were found in the tumour cells by immunohistochemistry. mRNA of group II phospholipase A2 was localized in the tumour cells by in situ hybridization. It was concluded that a considerable part of this rare type of tumour consisted of Paneth cells which were capable of synthesizing group II phospholipase A2.
本文报告一例51岁男性直肠绒毛管状腺瘤病例。肿瘤含有大量潘氏细胞，这些细胞在基底区域形成了发育良好的腺体。通过免疫组织化学在肿瘤细胞中发现了II型磷脂酶A2和溶菌酶。通过原位杂交将II型磷脂酶A2的mRNA定位在肿瘤细胞中。得出的结论是，这种罕见类型的肿瘤相当一部分由能够合成II型磷脂酶A2的潘氏细胞组成。
