Damilakis J, Perisinakis K, Vagios E, Tsinikas D, Gourtsoyiannis N
University of Crete, Faculty of Medicine, P.O. Box 1352, 711 10 Iraklion, Crete, Greece.
Calcif Tissue Int. 1998 Oct;63(4):300-5. doi: 10.1007/s002239900531.
Ultrasound (US) measurements of the calcaneus are usually carried out in a region of interest (ROI) at a fixed site relative to a footplate. Recently, US transmission systems have been developed with imaging capability that enable selection of the position of ROI; the region of measurement is always the area of minimum attenuation in the posterior part of the calcaneus. This study compares measurements of broadband ultrasound attenuation (BUA) and speed of sound (SOS) at the variable ROI of minimum attenuation (ROIv) and at fixed coordinates (ROIf). Ultrasound variables were estimated at ROIv and ROIf in 212 female subjects, including 26 patients with osteoporotic fractures. Among the 186 women without fractures, 63 were classified as having osteoporosis on the basis of their vertebral bone density. Precision of BUA and SOS were better at ROIv than at ROIf. BUA was more highly correlated with bone mineral density (BMD) at the lumbar spine and femoral neck at ROIv than ROIf (r = 0.64 for lumbar spine and 0.68 for femoral neck at ROIv versus 0.50 for lumbar spine and 0.54 for femoral neck at ROIf, P < 0.05 for both comparisons). There were no significant differences between the correlations of SOS with axial BMD at ROIv compared with ROIf. Significant difference was found between the areas under the ROC curve for each ultrasound variable at ROIv and ROIf for both groups of patients, subjects with osteoporosis (area under curve = 0.87 for BUA at ROIv versus 0.82 at ROIf, P < 0.05; area under curve = 0.85 for SOS at ROIv versus 0.81 at ROIf, P < 0. 05), and women with fractures (area under curve = 0.93 for BUA at ROIv versus 0.86 at ROIf, P < 0.05; area under curve = 0.91 for SOS at ROIv versus 0.82 at ROIf, P < 0.05). Ultrasound variables measured at ROIv enable improved reproducibility and significantly better differentiation of diseased subjects from healthy individuals as compared with measurements at ROIf.
跟骨的超声（US）测量通常在相对于脚踏板的固定部位的感兴趣区域（ROI）进行。最近，已开发出具有成像功能的US传输系统，可选择ROI的位置；测量区域始终是跟骨后部衰减最小的区域。本研究比较了在最小衰减可变ROI（ROIv）和固定坐标（ROIf）处的宽带超声衰减（BUA）和声速（SOS）测量值。在212名女性受试者中，包括26名骨质疏松性骨折患者，在ROIv和ROIf处估计超声变量。在186名无骨折的女性中，63名根据其椎体骨密度被分类为患有骨质疏松症。BUA和SOS在ROIv处的精度优于ROIf处。与ROIf相比，ROIv处的BUA与腰椎和股骨颈的骨密度（BMD）相关性更高（ROIv处腰椎r = 0.64，股骨颈r = 0.68；ROIf处腰椎r = 0.50，股骨颈r = 0.54，两组比较P < 0.05）。ROIv处SOS与轴向BMD的相关性与ROIf处相比无显著差异。在两组患者中，即骨质疏松症患者（ROIv处BUA曲线下面积 = 0.87，ROIf处为0.82，P < 0.05；ROIv处SOS曲线下面积 = 0.85，ROIf处为0.81，P < 0.05）和骨折女性（ROIv处BUA曲线下面积 = 0.93，ROIf处为0.86，P < 0.05；ROIv处SOS曲线下面积 = 0.91，ROIf处为0.82，P < 0.05），ROIv和ROIf处每个超声变量的ROC曲线下面积存在显著差异。与在ROIf处测量相比，在ROIv处测量的超声变量具有更高的可重复性，并且能更显著地区分患病个体与健康个体。
