虹鳟鱼（Oncorhynchus mykiss）寄生虫病的口服药物治疗。II. 三代虫属（Gyrodactylus sp.）

Oral pharmacological treatments for parasitic diseases of rainbow trout Oncorhynchus mykiss. II. Gyrodactylus sp.

作者信息

Tojo J L, Santamarina M T

机构信息

Department of Microbiology and Parasitology, Faculty of Pharmacy, Universidad de Santiago de Compostela, Spain.

出版信息

Dis Aquat Organ. 1998 Jul 30;33(3):187-93. doi: 10.3354/dao033187.

DOI:10.3354/dao033187

PMID:9745715

Abstract

A total of 24 drugs were evaluated as regards their efficacy for oral treatment of gyrodactylosis in rainbow trout Oncorhynchus mykiss. In preliminary trials, all drugs were supplied to infected fish at 40 g per kg of feed for 10 d. Twenty-two of the drugs tested (aminosidine, amprolium, benznidazole, bithionol, chloroquine, diethylcarbamazine, flubendazole, levamisole, mebendazole, metronidazole, niclosamide, nitroxynil, oxibendazole, parbendazole, piperazine, praziquantel, ronidazole, secnidazole, tetramisole, thiophanate, toltrazuril and trichlorfon) were ineffective. Triclabendazole and nitroscanate completely eliminated the infection. Triclabendazole was effective only at the screening dosage (40 g per kg of feed for 10 d), while nitroscanate was effective at dosages as low as 0.6 g per kg of feed for 1 d.

摘要

共评估了24种药物对虹鳟Oncorhynchus mykiss口腔三代虫病的治疗效果。在初步试验中，所有药物均以每千克饲料40克的剂量投喂感染鱼，持续10天。所测试的22种药物（氨基糖苷、氨丙啉、苯硝唑、硫双二氯酚、氯喹、乙胺嗪、氟苯达唑、左旋咪唑、甲苯达唑、甲硝唑、氯硝柳胺、硝羟碘苄腈、奥苯达唑、巴苯达唑、哌嗪、吡喹酮、罗硝唑、塞克硝唑、四咪唑、托布津、妥曲珠利和敌百虫）均无效。三氯苯达唑和硝碘酚腈完全消除了感染。三氯苯达唑仅在筛选剂量（每千克饲料40克，持续10天）下有效，而硝碘酚腈在低至每千克饲料0.6克的剂量下投喂1天就有效。