Thiery S, Misery L, Chossegros P, Kanitakis J, Ghohestani R, Forestier J Y, Trepo C, Faure M, Claudy A
Clinique Dermatologique, Hôpital Edouard Herriot, Lyon.
Ann Dermatol Venereol. 1998 Apr;125(4):264-7.
Epidermolysis bullosa acquisita is a bullous dermatosis. Its etiology remains unknown and the efficacy of its treatment is low.
We report the first association between epidermolysis bullosa acquisita, chronic hepatitis C and cryoglobulinemia, healing with interferon alpha and ribavirine.
We suggest a role for hepatitis C virus in the pathogenesis of epidermolysis bullosa acquisita. We suppose a synthesis of autoimmune antibodies in a dysimmune environment. Interferon alpha and ribavirine might be a new therapeutic avenue but further studies are necessary to confirm it.
获得性大疱性表皮松解症是一种大疱性皮肤病。其病因尚不清楚，治疗效果不佳。
我们报告了首例获得性大疱性表皮松解症、慢性丙型肝炎和冷球蛋白血症之间的关联，经α干扰素和利巴韦林治疗后痊愈。
我们认为丙型肝炎病毒在获得性大疱性表皮松解症的发病机制中起作用。我们推测在免疫失调的环境中会合成自身免疫抗体。α干扰素和利巴韦林可能是一种新的治疗途径，但需要进一步研究加以证实。
