Zvulunov A, Wyatt D T, Laud P W, Esterly N B
Division of Dermatology, Medical College of Wisconsin, Milwaukee 53226, USA.
Br J Dermatol. 1998 Jun;138(6):993-7. doi: 10.1046/j.1365-2133.1998.02265.x.
Females with Turner syndrome (TS) are alleged to have increased numbers of melanocytic naevi. Although a high count of acquired melanocytic naevi (AMN) is one of the major risk factors for melanoma, this malignancy has been reported only rarely in patients with TS. The purpose of this study was to explore the effects of environmental and genetic factors on AMN count and density in TS. AMN count and density in 24 patients with TS treated with growth hormone (GH). 24 GH-treated females with GH deficiency (GHD) and 24 normal females were compared in a cross-sectional study. The average AMN density in TS was 50 naevi/m2 as compared with 18 naevi/m2 in the GHD group and 24 naevi/m2 in normal controls (P = 0.001 and P = 0.004, respectively). Duration of GH therapy did not correlate with AMN count (P = 0.44) or AMN density (P = 0.81). The pattern of distribution of naevi between constantly exposed, intermittently exposed and unexposed skin was similar in all groups. Sun exposure was the major factor that affected the regional AMN densities in the control groups, but not in the TS group. The findings of our study indicate that the effects of environmental factors on AMN count and density may vary among genetically different populations. A review of the literature suggested that melanoma is no more prevalent in TS than in the general population.
据称，患有特纳综合征（TS）的女性黑素细胞痣数量会增加。虽然获得性黑素细胞痣（AMN）数量较多是黑色素瘤的主要危险因素之一，但TS患者中这种恶性肿瘤的报道却很少。本研究的目的是探讨环境和遗传因素对TS患者AMN数量和密度的影响。对24例接受生长激素（GH）治疗的TS患者的AMN数量和密度进行了研究。在一项横断面研究中，对24例接受GH治疗的生长激素缺乏症（GHD）女性和24例正常女性进行了比较。TS患者的平均AMN密度为50个痣/平方米，而GHD组为18个痣/平方米，正常对照组为24个痣/平方米（P分别为0.001和0.004）。GH治疗的持续时间与AMN数量（P = 0.44）或AMN密度（P = 0.81）均无相关性。所有组中，持续暴露、间歇暴露和未暴露皮肤之间痣的分布模式相似。阳光暴露是影响对照组区域AMN密度的主要因素，但对TS组无影响。我们的研究结果表明，环境因素对AMN数量和密度的影响在基因不同的人群中可能有所不同。文献综述表明，TS患者中黑色素瘤的患病率并不高于普通人群。
