Bourguignon J P, Piérard G E, Ernould C, Heinrichs C, Craen M, Rochiccioli P, Arrese J E, Franchimont C
Department of Paediatrics, University of Liège, Belgium.
Lancet. 1993 Jun 12;341(8859):1505-6. doi: 10.1016/0140-6736(93)90636-u.
Melanocytic naevi may grow more rapidly during human growth hormone (hGH) therapy. With standardised skin photographs, the growth rate of the naevi was two-fold greater in 14 hypopituitary and 5 Turner's syndrome girls treated with hGH than in untreated patients or controls. HMB-45 immunoreactivity, a marker of stimulated melanocytes, was absent in naevi from 18 of 19 individuals not treated with hGH, including 5 Turner's syndrome patients studied 2-43 months after stopping hGH. In naevi from 39 hGH-treated patients, 22 showed unusual HMB-45 reactivity in dermal naevocytes. During administration of hGH, melanocytic naevi grow faster and there is reversible stimulation of naevocytes.
黑素细胞痣在人生长激素（hGH）治疗期间可能生长得更快。通过标准化的皮肤照片发现，14名接受hGH治疗的垂体功能减退女孩和5名特纳综合征女孩的痣生长速度比未治疗的患者或对照组快两倍。HMB-45免疫反应性是黑素细胞受刺激的标志物，在19名未接受hGH治疗的个体（包括5名在停用hGH后2 - 43个月接受研究的特纳综合征患者）的痣中未检测到。在39名接受hGH治疗患者的痣中，22例在真皮痣细胞中表现出异常的HMB-45反应性。在hGH给药期间，黑素细胞痣生长更快，并且痣细胞受到可逆性刺激。
