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使用福尔马林固定切片及延迟闭合术治疗眼周基底细胞癌的莫氏手术

Mohs' surgery of periocular basal cell carcinoma using formalin-fixed sections and delayed closure.

作者信息

der Plessis P J, Dahl M G, Malcolm A J, Sviland L, Dickinson A J, Lawrence C M

机构信息

Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.

出版信息

Br J Dermatol. 1998 Jun;138(6):1003-8. doi: 10.1046/j.1365-2133.1998.02267.x.

Abstract

Mohs' surgery of periocular basal cell carcinoma (BCC) ensures a high cure rate with maximal preservation of normal tissue. The formalin-fixed paraffin-embedded tissue technique allows Mohs' surgery to be performed using routine pathology facilities and permits the efficient use of operating room personnel and theatre time. The inevitable delay between excision and closure may potentially result in a poor functional and cosmetic outcome, particularly around the eye. We prospectively studied all patients with periocular BCC treated with this technique at our unit between 1985 and 1996. One hundred and twenty-three periocular BCCs in 120 patients were treated. Microscopic clearance was achieved in all cases. Closure was performed on average 5 days after the initial excisional stage. Closing procedures included direct closure, flaps and grafts. Significant complications affecting outcome were noted in only two patients. Eighty-eight per cent of patients assessed had a functional and cosmetic result regarded as excellent, good or adequate. Mohs' surgery of periocular BCC using formalin-fixed paraffin-embedded tissue and delayed closure results in a satisfactory functional and cosmetic outcome and offers a viable alternative to the frozen section fresh tissue technique.

摘要

眼部周围基底细胞癌(BCC)的莫氏手术可确保高治愈率,并最大程度地保留正常组织。福尔马林固定石蜡包埋组织技术使莫氏手术能够利用常规病理设备进行,还能有效利用手术室人员和手术时间。切除与缝合之间不可避免的延迟可能会导致功能和美容效果不佳,尤其是在眼部周围。我们对1985年至1996年间在我们科室接受该技术治疗的所有眼部周围BCC患者进行了前瞻性研究。共治疗了120例患者的123处眼部周围BCC。所有病例均实现了显微镜下切缘阴性。在初始切除阶段后平均5天进行缝合。缝合程序包括直接缝合、皮瓣和植皮。仅在两名患者中发现了影响治疗结果的严重并发症。在接受评估的患者中,88%的患者功能和美容效果被评为优秀、良好或尚可。使用福尔马林固定石蜡包埋组织和延迟缝合的眼部周围BCC莫氏手术可带来令人满意的功能和美容效果,并为冰冻切片新鲜组织技术提供了可行的替代方案。

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