• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Herpesviral thymidine kinases: laxity and resistance by design.

作者信息

Evans J S, Lock K P, Levine B A, Champness J N, Sanderson M R, Summers W C, McLeish P J, Buchan A

机构信息

School of Biochemistry, and Department of Infection, University of Birmingham, UK.

出版信息

J Gen Virol. 1998 Sep;79 ( Pt 9):2083-92. doi: 10.1099/0022-1317-79-9-2083.

DOI:10.1099/0022-1317-79-9-2083
PMID:9747715
Abstract
摘要

相似文献

1
Herpesviral thymidine kinases: laxity and resistance by design.疱疹病毒胸苷激酶:设计所致的松弛性与耐药性
J Gen Virol. 1998 Sep;79 ( Pt 9):2083-92. doi: 10.1099/0022-1317-79-9-2083.
2
Evolution of herpesvirus thymidine kinases from cellular deoxycytidine kinase.疱疹病毒胸苷激酶由细胞脱氧胞苷激酶进化而来。
J Gen Virol. 1991 Oct;72 ( Pt 10):2583-6. doi: 10.1099/0022-1317-72-10-2583.
3
The nucleotide sequence of the equine herpesvirus 4 thymidine kinase gene.马疱疹病毒4型胸苷激酶基因的核苷酸序列。
J Gen Virol. 1990 Aug;71 ( Pt 8):1801-5. doi: 10.1099/0022-1317-71-8-1801.
4
Structure-specificity features of HSV-1 thymidine kinases.单纯疱疹病毒1型胸苷激酶的结构特异性特征。
Biochem Soc Trans. 1997 Nov;25(4):S621. doi: 10.1042/bst025s621.
5
The three-dimensional structure of thymidine kinase from herpes simplex virus type 1.单纯疱疹病毒1型胸苷激酶的三维结构
FEBS Lett. 1995 Jul 17;368(2):289-92. doi: 10.1016/0014-5793(95)00680-8.
6
Herpesviral deoxythymidine kinases contain a site analogous to the phosphoryl-binding arginine-rich region of porcine adenylate kinase; comparison of secondary structure predictions and conservation.疱疹病毒脱氧胸苷激酶含有一个与猪腺苷酸激酶富含精氨酸的磷酰结合区域类似的位点;二级结构预测与保守性比较。
J Gen Virol. 1990 Dec;71 ( Pt 12):2979-87. doi: 10.1099/0022-1317-71-12-2979.
7
Structure of a type II thymidine kinase with bound dTTP.结合dTTP的II型胸苷激酶的结构
FEBS Lett. 2005 Feb 28;579(6):1376-82. doi: 10.1016/j.febslet.2005.01.034.
8
Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir.单纯疱疹病毒1型胸苷激酶与脱氧胸苷和更昔洛韦复合物的晶体结构。
Nat Struct Biol. 1995 Oct;2(10):876-81. doi: 10.1038/nsb1095-876.
9
Nucleotide and predicted amino acid sequences of the Marek's disease virus and turkey herpesvirus thymidine kinase genes; comparison with thymidine kinase genes of other herpesviruses.马立克氏病病毒和火鸡疱疹病毒胸苷激酶基因的核苷酸及预测氨基酸序列;与其他疱疹病毒胸苷激酶基因的比较。
J Gen Virol. 1989 Nov;70 ( Pt 11):3055-65. doi: 10.1099/0022-1317-70-11-3055.
10
The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogue.1型单纯疱疹病毒胸苷激酶与底物及底物类似物复合物的结构
Protein Sci. 1997 Oct;6(10):2097-106. doi: 10.1002/pro.5560061005.

引用本文的文献

1
Antiviral Drugs Against Herpesviruses.抗疱疹病毒药物。
Adv Exp Med Biol. 2021;1322:1-30. doi: 10.1007/978-981-16-0267-2_1.
2
Activity and mechanism of action of HDVD, a novel pyrimidine nucleoside derivative with high levels of selectivity and potency against gammaherpesviruses.新型嘧啶核苷衍生物 HDVD 对γ疱疹病毒具有高选择性和高效性的作用机制与活性。
J Virol. 2013 Apr;87(7):3839-51. doi: 10.1128/JVI.03338-12. Epub 2013 Jan 23.
3
Neonatal herpes encephalitis caused by a virologically confirmed acyclovir-resistant herpes simplex virus 1 strain.
由经病毒学证实的阿昔洛韦耐药单纯疱疹病毒 1 株引起的新生儿疱疹性脑炎。
J Clin Microbiol. 2013 Jan;51(1):356-9. doi: 10.1128/JCM.02247-12. Epub 2012 Oct 24.
4
iGEMDOCK: a graphical environment of enhancing GEMDOCK using pharmacological interactions and post-screening analysis.iGEMDOCK:一个利用药理学相互作用和筛选后分析增强 GEMDOCK 的图形化环境。
BMC Bioinformatics. 2011 Feb 15;12 Suppl 1(Suppl 1):S33. doi: 10.1186/1471-2105-12-S1-S33.
5
Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management.单纯疱疹病毒对核苷类似物的耐药性:机制、流行率和管理。
Antimicrob Agents Chemother. 2011 Feb;55(2):459-72. doi: 10.1128/AAC.00615-10. Epub 2010 Nov 15.
6
SiMMap: a web server for inferring site-moiety map to recognize interaction preferences between protein pockets and compound moieties.SiMMap:一个用于推断位点-基团图以识别蛋白质口袋和化合物基团之间相互作用偏好的网络服务器。
Nucleic Acids Res. 2010 Jul;38(Web Server issue):W424-30. doi: 10.1093/nar/gkq480. Epub 2010 Jun 2.
7
Characterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudin.在一轮高剂量溴夫定作用下筛选出的单纯疱疹病毒1型胸苷激酶突变体的特性分析
J Virol. 2005 May;79(9):5863-9. doi: 10.1128/JVI.79.9.5863-5869.2005.
8
Herpes simplex virus thymidine kinase mutations associated with resistance to acyclovir: a site-directed mutagenesis study.与阿昔洛韦耐药相关的单纯疱疹病毒胸苷激酶突变:一项定点诱变研究。
Antimicrob Agents Chemother. 2005 Mar;49(3):1055-9. doi: 10.1128/AAC.49.3.1055-1059.2005.