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在英国一所大学校园风疹疫情爆发后开展麻疹/风疹疫苗接种活动的实施与评估。

Implementation and evaluation of a measles/rubella vaccination campaign in a campus university in the UK following an outbreak of rubella.

作者信息

Stevenson J, Murdoch G, Riley A, Duncan B, McWhirter M, Christie P

机构信息

Argyll and Clyde Health Board, Paisley, UK.

出版信息

Epidemiol Infect. 1998 Aug;121(1):157-64. doi: 10.1017/s0950268898001071.

Abstract

An age shift in rubella infection to young adults has occurred in Scotland since the introduction of a first dose measles, mumps and rubella (MMR) vaccination in 1988 and a second dose measles/rubella (MR) vaccination in 1994/95. The Health Board was alerted to an outbreak of rubella at Stirling University by the notification of 6 cases amongst male students aged 18-28 years with dates of onset between 3 March and 21 March 1996. In response, a MR vaccination campaign was conducted to enhance population immunity to rubella within the university population and to reduce the likelihood of further cases. A total of 1795 students, staff and visitors were vaccinated. Vaccine coverage of 46% was estimated to be sufficient to boost rubella immunity in full time male students in university accommodation to 88.7-91.0%, just above the upper critical level of herd immunity for rubella of 85-88%. Students in colleges and universities in the UK will remain at increased risk of outbreaks of rubella and measles until the cohort who have received a two dose schedule of MR form the bulk of the college population. It may be prudent for tertiary education colleges and other institutions in the UK with young adults living in shared residential accommodation to offer MR vaccination to new entrants, targeting those who have not previously received the vaccine, between now and the year 2000.

摘要

自1988年引入首剂麻疹、腮腺炎和风疹(MMR)疫苗以及1994/1995年引入第二剂麻疹/风疹(MR)疫苗以来,苏格兰风疹感染的年龄分布已向年轻人转移。斯特灵大学通报了1996年3月3日至3月21日期间18至28岁男学生中的6例风疹病例,卫生委员会因此收到警报。作为应对措施,开展了一次MR疫苗接种活动,以增强大学人群对风疹的群体免疫力,并降低进一步出现病例的可能性。共有1795名学生、教职员工和访客接种了疫苗。据估计,46%的疫苗接种覆盖率足以将大学宿舍全日制男学生的风疹免疫力提高到88.7%至91.0%,略高于风疹群体免疫的临界上限85%至88%。在接受两剂次MR疫苗接种的人群成为大学人口的主体之前,英国大专院校的学生感染风疹和麻疹的风险仍将增加。对于英国那些有年轻人居住在共享宿舍的高等教育学院和其他机构来说,在现在至2000年期间,向新入学学生提供MR疫苗接种,针对那些以前未接种过疫苗的学生,可能是谨慎之举。

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