Li W, Fann C S, Ott J
Rockefeller University, New York, N.Y., USA.
Hum Hered. 1998 Sep-Oct;48(5):266-70. doi: 10.1159/000022814.
Recombination rates in humans tend to be sex specific. For a given map interval delimited by genetic markers, the difference between male and female recombination rates may be measured by the ratio, R, of female-to-male map distance. On average over all chromosomes, R is close to 2, but this ratio is region specific. The spatial variation of R can be captured by a low-order (linear, quadratic, etc.) trend across the length of the chromosome. Chromosome maps have been constructed that take into account such trends. Resulting map distances tend to be more accurate than when such trends are ignored. These maps may be obtained at URL ftp://linkage.rockefeller.edu/SexSpecMaps/.
人类的重组率往往具有性别特异性。对于由遗传标记界定的给定图谱区间，男性和女性重组率之间的差异可以通过女性与男性图谱距离的比率R来衡量。在所有染色体上平均而言，R接近2，但这个比率是区域特异性的。R的空间变化可以通过沿着染色体长度的低阶（线性、二次等）趋势来捕捉。已经构建了考虑到这种趋势的染色体图谱。由此得到的图谱距离往往比忽略这种趋势时更准确。这些图谱可从URL ftp://linkage.rockefeller.edu/SexSpecMaps/获取。
