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[糖尿病患者冠状动脉支架植入术。短期和中期临床结果]

[Implantation of coronary stents in diabetic patients. Short- and medium-term clinical results].

作者信息

Joseph T, Fajadet J, Laurent J P, Jordan C, Cassagneau B, Laborde J C, Marco J

机构信息

Service de cardiologie, hôpital Ambroise-Pare, Boulogne-Billancourt.

出版信息

Arch Mal Coeur Vaiss. 1998 Jun;91(6):715-20.

PMID:9749187
Abstract

Coronary balloon angioplasty is associated with a high incidence of restenosis in diabetics and of revascularisation of the culprit lesion and increased long-term mortality. The authors report the short and medium-term results of coronary stenting in diabetics. Between May 1995 and April 1997, 2,182 patients underwent coronary stenting. This population included 272 diabetics : 58 insulin-dependent and 214 non-insulin dependent (oral antidiabetics). Stents were implanted in vessels with mean diameters of 3 mm and over. During the hospital period, the complication rate (mortality, non-fatal myocardial infarction, emergency coronary bypass surgery, subacute thrombosis of the stent) was comparable in non-diabetics, insulin-dependent and non-insulin-dependent diabetics (2.55, 0 and 2.0% respectively). One patient (0.5%) died and another (0.5%) had non-fatal myocardial infarction (thrombosis of the stent) in the non-insulin-dependent group. No complications were observed in the insulin-dependent diabetic group. The mean clinical follow-up of 13 months (3-26 months) was respected in 93 and 97% of diabetics. The non-fatal myocardial infarction rate and revascularisation of the culprit lesion were comparable in the insulin and non-insulin-dependent groups (0 versus 0.5% and 8.2 versus 10.5% respectively) but global mortality was higher in the insulin-dependent diabetics (9.3 versus 2.4%).

摘要

冠状动脉球囊血管成形术与糖尿病患者再狭窄的高发生率、罪犯病变血管重建以及长期死亡率增加相关。作者报告了糖尿病患者冠状动脉支架置入术的短期和中期结果。1995年5月至1997年4月期间,2182例患者接受了冠状动脉支架置入术。该人群包括272例糖尿病患者:58例胰岛素依赖型和214例非胰岛素依赖型(口服降糖药)。支架植入平均直径3毫米及以上的血管。在住院期间,非糖尿病患者、胰岛素依赖型和非胰岛素依赖型糖尿病患者的并发症发生率(死亡率、非致命性心肌梗死、急诊冠状动脉搭桥手术、支架亚急性血栓形成)相当(分别为2.55%、0和2.0%)。非胰岛素依赖型组有1例患者(0.5%)死亡,另1例(0.5%)发生非致命性心肌梗死(支架血栓形成)。胰岛素依赖型糖尿病组未观察到并发症。93%和97%的糖尿病患者分别接受了平均13个月(3 - 26个月)的临床随访。胰岛素依赖型和非胰岛素依赖型组的非致命性心肌梗死发生率和罪犯病变血管重建率相当(分别为0对0.5%和8.2%对10.5%),但胰岛素依赖型糖尿病患者的总体死亡率更高(9.3%对2.4%)。

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