多中心试验规划与分析中的一些争议。
Some controversies in planning and analysing multi-centre trials.
作者信息
Senn S
机构信息
Department of Statistical Science, University College London, U.K.
出版信息
Stat Med. 1998;17(15-16):1753-65; discussion 1799-800. doi: 10.1002/(sici)1097-0258(19980815/30)17:15/16<1753::aid-sim977>3.0.co;2-x.
Abstract
It is shown that a rational approach to planning multi-centre trials will lead to an unequal distribution of patients across centres. Consequently different approaches to estimation will yield different estimates. However, some such approaches are not reasonable and it is concluded that multi-centre trials are less problematic than is commonly supposed.
摘要
结果表明，采用合理的方法规划多中心试验会导致各中心患者分布不均。因此，不同的估计方法会得出不同的估计结果。然而，有些此类方法并不合理，得出的结论是多中心试验的问题比通常认为的要少。
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