Hirschl S, Black M M, Kwon C S
Cancer. 1976 Aug;38(2):807-17. doi: 10.1002/1097-0142(197608)38:2<807::aid-cncr2820380224>3.0.co;2-8.
An ultrastructural study of sinus histiocytosis (SH) in axillary lymph nodes was undertaken in 20 patients with primary cancer of the breast. The lymph node responses were first classified by means of light microscopy, according to previously established criteria. The ultrastructural findings established three major patterns of SH response in cancer-draining lymph nodes: developing SH, positive SH, and degenerative SH. These patterns followed closely the classification obtained by light microscopy. An important finding of electron microscopy was the presence of early activation of histiocytes (developing SH) in microscopy (negative SH). The striking ultrastructural resemblance of histiocytes in positive SH to epithelioid cells seen in delayed hypersensitivity reactions (TB) again points to the fact that the positive SH pattern represents a tumor-host reaction of the delayed hypersensitivity type. Finally, although the presence of virus has been shown to play a role in spontaneous BALB/c murine breast tumor, no virions could be found in human cancer-draining lymph nodes.
对20例原发性乳腺癌患者的腋窝淋巴结窦组织细胞增生症（SH）进行了超微结构研究。首先根据先前确立的标准，通过光学显微镜对淋巴结反应进行分类。超微结构研究结果确定了癌引流淋巴结中SH反应的三种主要模式：进展期SH、阳性SH和退化期SH。这些模式与光学显微镜下的分类结果密切相关。电子显微镜的一个重要发现是在光学显微镜下呈阴性的SH中存在组织细胞的早期激活（进展期SH）。阳性SH中的组织细胞与迟发型超敏反应（结核病）中所见的上皮样细胞在超微结构上惊人地相似，这再次表明阳性SH模式代表了迟发型超敏反应类型的肿瘤-宿主反应。最后，虽然已证明病毒在自发的BALB/c小鼠乳腺肿瘤中起作用，但在人类癌引流淋巴结中未发现病毒粒子。
