基因调控过程中DNA螺旋开口的选择性控制。

Cancer Res. 1976 Sep;36(9 PT 2):3394-8.

DNA helices must undergo openings in the form of localized strand separations in order to permit the onset of RNA synthesis or DNA synthesis. The selective control of such DNA helix openings at particular gene loci is the critical feature of gene regulation in prokaryotes and eukaryotes.

DNA螺旋必须以局部链分离的形式发生解旋，以便启动RNA合成或DNA合成。在特定基因位点对这种DNA螺旋解旋的选择性控制是原核生物和真核生物基因调控的关键特征。