Paschka A G, Butler R, Young C Y
Department of Urology, Mayo Clinic/Foundation, Rochester, MN 55905, USA.
Cancer Lett. 1998 Aug 14;130(1-2):1-7. doi: 10.1016/s0304-3835(98)00084-6.
Green tea components exert many biological effects, including antitumor and cancer preventive activities. In the search for anticancer agents for prostate cancer the inhibitory effects of green tea components were tested on the prostate cancer cell lines LNCaP, PC-3 and DU145. (-)-Epigallocatechin-3-gallate (EGCG) proved to be the most potent catechin at inhibiting cell growth. The inhibition induced by EGCG was found to occur via apoptotic cell death as shown by changes in nuclear morphology and DNA fragmentation. Thus, we report the first evidence that EGCG is the active component in green tea and induces apoptosis in human prostate cancer cells.
绿茶成分具有多种生物学效应，包括抗肿瘤和防癌活性。在寻找前列腺癌抗癌药物的过程中，测试了绿茶成分对前列腺癌细胞系LNCaP、PC-3和DU145的抑制作用。（-）-表没食子儿茶素-3-没食子酸酯（EGCG）被证明是抑制细胞生长最有效的儿茶素。如核形态变化和DNA片段化所示，发现EGCG诱导的抑制作用是通过凋亡性细胞死亡发生的。因此，我们首次报道了EGCG是绿茶中的活性成分并能诱导人前列腺癌细胞凋亡的证据。
