Barbagli G, Palminteri E, Rizzo M
Department of Urology, University of Florence, Italy.
J Urol. 1998 Oct;160(4):1307-9.
Preputial skin graft is used routinely for urethral reconstruction in patients with stricture disease. Alternative donor sites include extrapenile skin, bladder mucosa and buccal mucosa. Recently buccal mucosa graft has been suggested when local epithelial tissue is not available. We describe our experience with 37 patients undergoing 1-stage correction of bulbar urethral stricture using a penile skin (31) or buccal mucosa (6) graft.
In 37 patients with bulbar urethral strictures a nontubularized dorsal onlay graft was used for urethral reconstruction. A preputial skin graft was used in 31 patients and a buccal mucosa graft in 6 with a paucity of local skin. Buccal mucosa graft length ranged from 2.5 to 5 cm. (average 4) and preputial skin graft was 2.5 to 12 cm. long (average 4.7). A dorsal approach to the urethral lumen was used in all patients who underwent onlay graft urethroplasty.
Mean followup was 21.5 months for all 37 patients, 23 months for 31 treated with preputial skin graft and 13.5 months for 6 treated with buccal mucosa graft. The clinical outcomes were considered a failure anytime postoperative instrumentation was needed, including dilatation. In the series 34 cases (92%) were classified as a success and 3 (8%) as failure.
Onlay graft urethroplasty provided excellent results in 92% of adults with bulbourethral stricture. The dorsal approach to the urethra allowed the use of foreskin or buccal mucosa graft for reconstruction of the adequate urethral lumen.
包皮皮肤移植常用于狭窄疾病患者的尿道重建。其他供区包括阴茎外皮肤、膀胱黏膜和颊黏膜。近来,当局部上皮组织不可用时,有人建议使用颊黏膜移植。我们描述了37例行球部尿道狭窄一期矫正术患者使用阴茎皮肤(31例)或颊黏膜(6例)移植的经验。
37例球部尿道狭窄患者采用非管状化背侧镶嵌移植进行尿道重建。31例患者使用包皮皮肤移植,6例局部皮肤不足者使用颊黏膜移植。颊黏膜移植长度为2.5至5厘米(平均4厘米),包皮皮肤移植长度为2.5至12厘米(平均4.7厘米)。所有接受镶嵌移植尿道成形术的患者均采用经尿道背侧入路。
37例患者平均随访21.5个月,31例接受包皮皮肤移植者随访23个月,6例接受颊黏膜移植者随访13.5个月。术后任何时候需要器械操作(包括扩张)时,临床结果均视为失败。本系列中34例(92%)为成功,3例(8%)为失败。
镶嵌移植尿道成形术在92%的成人球部尿道狭窄患者中取得了优异的效果。经尿道背侧入路允许使用包皮或颊黏膜移植来重建足够的尿道腔。