Morey A F, McAninch J W
Department of Urology, University of California School of Medicine, San Francisco 94143-0738, USA.
Urology. 1996 Aug;48(2):194-8. doi: 10.1016/S0090-4295(96)00154-9.
To evaluate the efficacy of buccal mucosa in the repair of adult urethral stricture disease, we report our experience with its use as a nontubularized onlay graft during bulbar urethral reconstruction.
From June 1993 to January 1996, 75 men underwent anterior urethral reconstruction for stricture disease. Single-stage urethroplasty with an onlay patch graft of buccal mucosa was performed in 13 patients with complex, refractory strictures of the bulbar urethra. In all cases, a two-team approach was used in which one team harvested the graft from the mouth while the perineal team simultaneously exposed and calibrated the stricture.
The length of buccal mucosa ranged from 3.5 to 17 cm (average length 6.2). In 8 patients, other reconstructive techniques were used concomitantly, including fasciocutaneous penile flap or stricture excision and primary anastomosis, depending on the length and severity of the scarred area. Median follow-up time was 18 months. Excellent results were obtained in all 13 patients, and none has required urethral dilation or instrumentation subsequently. Operative time was significantly less than with other forms of substitution urethroplasty.
Excellent results can be expected when buccal mucosa is used for urethral substitution in men with refractory bulbar strictures. For patients with long or dense strictures, buccal mucosal grafts may easily be combined with other reconstructive techniques. In patients with less complex stricture disease, the reduced operative time of this two-team approach may be beneficial.
为评估颊黏膜修复成人尿道狭窄疾病的疗效,我们报告了将其作为球部尿道重建术中非管状覆盖移植物的应用经验。
1993年6月至1996年1月,75名男性因狭窄疾病接受了前尿道重建手术。13例患有复杂难治性球部尿道狭窄的患者接受了颊黏膜覆盖补片移植的一期尿道成形术。在所有病例中,采用双组手术方式,一组从口腔获取移植物,而会阴组同时暴露并校准狭窄部位。
颊黏膜长度为3.5至17厘米(平均长度6.2厘米)。8例患者同时采用了其他重建技术,包括根据瘢痕区域的长度和严重程度采用阴茎筋膜皮瓣或狭窄切除及一期吻合术。中位随访时间为18个月。所有13例患者均取得了优异的效果,且此后均无需进行尿道扩张或器械操作。手术时间明显短于其他形式的替代尿道成形术。
对于患有难治性球部狭窄的男性,使用颊黏膜进行尿道替代可预期取得优异的效果。对于患有长段或致密狭窄的患者,颊黏膜移植物可轻松与其他重建技术联合使用。对于狭窄疾病不太复杂的患者,这种双组手术方式减少的手术时间可能有益。