Hudspeth A J, Tanaka K
Curr Opin Neurobiol. 1998 Aug;8(4):443-6. doi: 10.1016/s0959-4388(98)80029-9.
Research on the senses spans the enormous range from analysis of individual molecules involved in sensory transduction to the attempted elucidation of conscious sensation. Because the variety of conceptual and experimental approaches varies so broadly across the field, it is impossible to delineate a single direction for future research. Two trends are nonetheless apparent. At the reductionistic end of the spectrum, in the analysis of sensory transduction, studies on all the senses will increasingly be driven by the techniques of molecular biology. The advent of techniques for producing cDNA libraries from small ensembles of receptor cells, or even from individual cells, will permit the recognition of new constituents of receptor cells and of factors involved in their specification, differentiation, and maintenance. In the integrative realm of sensory neurobiology, future studies will increasingly rely on optical techniques for the study of activity patterns on the surfaces of sensory areas of the cerebral cortex and on noninvasive functional imaging for the investigation of neural responses in human subjects. These techniques will continue to strengthen our understanding of the relation between neuronal activity and conscious sensory experience.
对感官的研究涵盖了从参与感官转导的单个分子的分析到对有意识感觉的阐释的广泛领域。由于整个领域的概念和实验方法种类繁多,因此不可能为未来的研究划定单一方向。然而,有两个趋势是显而易见的。在光谱的还原论一端,在感官转导分析中,对所有感官的研究将越来越受到分子生物学技术的推动。从小群受体细胞甚至单个细胞中产生cDNA文库的技术的出现,将有助于识别受体细胞的新成分以及参与其特化、分化和维持的因素。在感官神经生物学的整合领域,未来的研究将越来越依赖光学技术来研究大脑皮层感觉区域表面的活动模式,并依赖非侵入性功能成像来研究人类受试者的神经反应。这些技术将继续加强我们对神经元活动与有意识感官体验之间关系的理解。