转座因子I因子（果蝇中一种类似LINE的元件）的拷贝数控制
Copy number control of a transposable element, the I factor, a LINE-like element in Drosophila.
作者信息
Chaboissier M C, Bucheton A, Finnegan D J
机构信息
Centre de Génétique Moléculaire du Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette, France.
出版信息
Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11781-5. doi: 10.1073/pnas.95.20.11781.
Abstract
The I factor is a LINE-like transposable element in Drosophila. Most strains of Drosophila melanogaster, inducer strains, contain 10-15 copies of the I factor per haploid genome located in the euchromatic regions of the chromosome arms. These are not present in a few strains known as reactive strains. I factors transpose at low frequency in inducer strains but at high frequency in the female progeny of crosses between reactive and inducer flies. We have found that the activity of the I factor promoter is sensitive to the number of copies of the first 186 nucleotides of the I factor sequence, which constitutes the 5'-untranslated region. The activity of the I factor decreases as the copy number of this sequence increases.
摘要
I因子是果蝇中一种类似LINE的转座元件。大多数黑腹果蝇品系，即诱导品系，每个单倍体基因组在染色体臂的常染色质区域含有10 - 15个I因子拷贝。而在一些被称为反应品系的少数品系中不存在这些拷贝。I因子在诱导品系中低频转座，但在反应品系和诱导品系杂交的雌性后代中高频转座。我们发现I因子启动子的活性对构成5'非翻译区的I因子序列前186个核苷酸的拷贝数敏感。随着该序列拷贝数的增加，I因子的活性降低。
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