• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4(+) T cells: role of signal transduction.CC趋化因子增强HIV-1 T嗜性毒株在CD4(+) T细胞中的复制：信号转导的作用
Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11880-5. doi: 10.1073/pnas.95.20.11880.
2
Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines.CC和CXC趋化因子对1型人类免疫缺陷病毒复制的遗传亚型非依赖性抑制作用
J Virol. 1998 Jan;72(1):396-404. doi: 10.1128/JVI.72.1.396-404.1998.
3
RANTES and MCP-3 inhibit the replication of T-cell-tropic human immunodeficiency virus type 1 strains (SF-2, MN, and HE).调节激活正常T细胞表达和分泌的趋化因子（RANTES）和单核细胞趋化蛋白-3（MCP-3）可抑制亲T细胞性1型人类免疫缺陷病毒毒株（SF-2、MN和HE）的复制。
J Virol. 1997 Oct;71(10):7300-4. doi: 10.1128/JVI.71.10.7300-7304.1997.
4
Increased replication of T-cell-tropic HIV strains and CXC-chemokine receptor-4 induction in T cells treated with macrophage inflammatory protein (MIP)-1alpha, MIP-1beta and RANTES beta-chemokines.在用巨噬细胞炎性蛋白（MIP）-1α、MIP-1β和调节激活正常T细胞表达和分泌因子（RANTES）β趋化因子处理的T细胞中，嗜T细胞性HIV毒株的复制增加以及CXC趋化因子受体4的诱导。
AIDS. 1998 Jan 22;12(2):183-90. doi: 10.1097/00002030-199802000-00008.
5
Hemofiltrate CC chemokine 1[9-74] causes effective internalization of CCR5 and is a potent inhibitor of R5-tropic human immunodeficiency virus type 1 strains in primary T cells and macrophages.血液滤过CC趋化因子1[9-74]可促使CCR5有效内化，并且是原代T细胞和巨噬细胞中R5嗜性1型人类免疫缺陷病毒毒株的强效抑制剂。
Antimicrob Agents Chemother. 2002 Apr;46(4):982-90. doi: 10.1128/AAC.46.4.982-990.2002.
6
Up-regulation of HIV coreceptors CXCR4 and CCR5 on CD4(+) T cells during human endotoxemia and after stimulation with (myco)bacterial antigens: the role of cytokines.人类内毒素血症期间及（分支）杆菌抗原刺激后CD4(+) T细胞上HIV共受体CXCR4和CCR5的上调：细胞因子的作用
Blood. 2000 Oct 15;96(8):2649-54.
7
Blockade of CC chemokine receptor 5 (CCR5)-tropic human immunodeficiency virus-1 replication in human lymphoid tissue by CC chemokines.CC趋化因子通过阻断CC趋化因子受体5（CCR5）嗜性的人类免疫缺陷病毒1在人类淋巴组织中的复制
J Clin Invest. 1998 May 1;101(9):1876-80. doi: 10.1172/JCI2015.
8
Inhibition of R5-tropic HIV type-1 replication in CD4⁺ natural killer T cells by γδ T lymphocytes.γδ T 淋巴细胞抑制 CD4⁺自然杀伤 T 细胞中 R5 嗜性 HIV-1 的复制。
Immunology. 2014 Apr;141(4):596-608. doi: 10.1111/imm.12221.
9
Natural killer cells from human immunodeficiency virus (HIV)-infected individuals are an important source of CC-chemokines and suppress HIV-1 entry and replication in vitro.来自人类免疫缺陷病毒（HIV）感染者的自然杀伤细胞是CC趋化因子的重要来源，并且在体外可抑制HIV-1的进入和复制。
J Clin Invest. 1998 Jul 1;102(1):223-31. doi: 10.1172/JCI2323.
10
Lineage-specific expression of human immunodeficiency virus (HIV) receptor/coreceptors in differentiating hematopoietic precursors: correlation with susceptibility to T- and M-tropic HIV and chemokine-mediated HIV resistance.人类免疫缺陷病毒（HIV）受体/共受体在分化的造血前体细胞中的谱系特异性表达：与对T嗜性和M嗜性HIV的易感性及趋化因子介导的HIV抗性的相关性
Blood. 1999 Sep 1;94(5):1590-600.

引用本文的文献

1
Macrophage-Derived Factors with the Potential to Contribute to Pathogenicity of HIV-1 and HIV-2: Role of CCL-2/MCP-1.巨噬细胞衍生因子对 HIV-1 和 HIV-2 致病性的潜在作用：CCL-2/MCP-1 的作用。
Viruses. 2023 Oct 27;15(11):2160. doi: 10.3390/v15112160.
2
Effects of Chemokine Ligand 2 on Budding of Bovine Foamy Virus.趋化因子配体 2 对牛泡沫病毒出芽的影响。
Viruses. 2023 Sep 1;15(9):1867. doi: 10.3390/v15091867.
3
Endogenous Peptide Inhibitors of HIV Entry.HIV 进入的内源性肽抑制剂。
Adv Exp Med Biol. 2022;1366:65-85. doi: 10.1007/978-981-16-8702-0_5.
4
The CD8 T Cell Noncytotoxic Antiviral Responses.CD8 T 细胞非细胞毒性抗病毒反应。
Microbiol Mol Biol Rev. 2021 May 12;85(2). doi: 10.1128/MMBR.00155-20. Print 2021 May 19.
5
The -HIV syndemic interaction: why treating infection may be crucial for HIV-1 eradication.-人类免疫缺陷病毒（HIV）共病交互作用：为何治疗感染可能对根除HIV-1至关重要。
Future Virol. 2020 Feb;15(2):101-125. doi: 10.2217/fvl-2019-0069.
6
CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release.CCL2 募集 ALIX 以促进 Gag-p6 介导的 HIV-1 病毒粒子释放。
Elife. 2019 Jun 7;8:e35546. doi: 10.7554/eLife.35546.
7
RANTES Gene Polymorphisms Associated with HIV-1 Infections in Kenyan Population.肯尼亚人群中与HIV-1感染相关的RANTES基因多态性
Dis Markers. 2016;2016:4703854. doi: 10.1155/2016/4703854. Epub 2016 Oct 16.
8
HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells.HIV潜伏期在静息和活化的原代CD4 T细胞中直接且早期建立。
PLoS Pathog. 2015 Jun 11;11(6):e1004955. doi: 10.1371/journal.ppat.1004955. eCollection 2015 Jun.
9
HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-κB, AP-1, C/EBPα and C/EBPγ transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways.HIV-1反式激活因子介导的星形胶质细胞中CCL5的诱导涉及核因子κB、激活蛋白-1、C/EBPα和C/EBPγ转录因子以及JAK、PI3K/Akt和p38丝裂原活化蛋白激酶信号通路。
PLoS One. 2013 Nov 11;8(11):e78855. doi: 10.1371/journal.pone.0078855. eCollection 2013.
10
Peptide and protein-based inhibitors of HIV-1 co-receptors.HIV-1 共受体的肽和蛋白质抑制剂。
Exp Biol Med (Maywood). 2013 May;238(5):442-9. doi: 10.1177/1535370213480696.

本文引用的文献

1
Actin-dependent receptor colocalization required for human immunodeficiency virus entry into host cells.人类免疫缺陷病毒进入宿主细胞所需的肌动蛋白依赖性受体共定位。
J Virol. 1998 Jun;72(6):5251-5. doi: 10.1128/JVI.72.6.5251-5255.1998.
2
Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity.氨氧基戊烷-调节激活正常T细胞表达和分泌因子（RANTES）诱导CCR5内化但抑制再循环：一种新的HIV感染抑制机制
J Exp Med. 1998 Apr 20;187(8):1215-24. doi: 10.1084/jem.187.8.1215.
3
Dichotomous effects of beta-chemokines on HIV replication in monocytes and monocyte-derived macrophages.β趋化因子对单核细胞及单核细胞衍生巨噬细胞中HIV复制的二分效应。
J Immunol. 1998 Apr 1;160(7):3091-5.
4
Increased replication of T-cell-tropic HIV strains and CXC-chemokine receptor-4 induction in T cells treated with macrophage inflammatory protein (MIP)-1alpha, MIP-1beta and RANTES beta-chemokines.在用巨噬细胞炎性蛋白（MIP）-1α、MIP-1β和调节激活正常T细胞表达和分泌因子（RANTES）β趋化因子处理的T细胞中，嗜T细胞性HIV毒株的复制增加以及CXC趋化因子受体4的诱导。
AIDS. 1998 Jan 22;12(2):183-90. doi: 10.1097/00002030-199802000-00008.
5
HIV type 1 V3 variation dynamics in vivo: long-term persistence of non-syncytium-inducing genotypes and transient presence of syncytium-inducing genotypes during the course of progressive AIDS.1型人类免疫缺陷病毒（HIV-1）V3区体内变异动态：非合胞体诱导基因型的长期持续存在以及在进行性艾滋病病程中合胞体诱导基因型的短暂出现。
AIDS Res Hum Retroviruses. 1997 Dec 10;13(18):1597-609. doi: 10.1089/aid.1997.13.1597.
6
HIV-1 gp120 induces an association between CD4 and the chemokine receptor CXCR4.人类免疫缺陷病毒1型糖蛋白120（HIV-1 gp120）诱导CD4与趋化因子受体CXCR4之间产生关联。
J Immunol. 1997 Sep 15;159(6):3000-8.
7
Polarization of chemokine receptors to the leading edge during lymphocyte chemotaxis.淋巴细胞趋化作用过程中趋化因子受体向前沿的极化。
J Exp Med. 1997 Jul 7;186(1):153-8. doi: 10.1084/jem.186.1.153.
8
Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.一种新型CCR5拮抗剂对巨噬细胞和淋巴细胞中HIV-1感染性的强效抑制作用。
Science. 1997 Apr 11;276(5310):276-9. doi: 10.1126/science.276.5310.276.
9
Evolutionary mechanisms and population dynamics of the third variable envelope region of HIV within single hosts.单一宿主内HIV第三个可变包膜区域的进化机制与种群动态
Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1264-9. doi: 10.1073/pnas.94.4.1264.
10
Change in coreceptor use correlates with disease progression in HIV-1--infected individuals.共受体使用情况的变化与HIV-1感染个体的疾病进展相关。
J Exp Med. 1997 Feb 17;185(4):621-8. doi: 10.1084/jem.185.4.621.

CC趋化因子增强HIV-1 T嗜性毒株在CD4(+) T细胞中的复制：信号转导的作用

CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4(+) T cells: role of signal transduction.

作者信息

Kinter A, Catanzaro A, Monaco J, Ruiz M, Justement J, Moir S, Arthos J, Oliva A, Ehler L, Mizell S, Jackson R, Ostrowski M, Hoxie J, Offord R, Fauci A S

机构信息

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11880-5. doi: 10.1073/pnas.95.20.11880.

DOI:10.1073/pnas.95.20.11880
PMID:9751759
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC21734/
Abstract

This study demonstrates that several CC-chemokines, including those that inhibit entry and replication of macrophage-tropic strains of HIV, increase the replication of T cell (T)-tropic strains in CD4(+) T cells. Enhancement of T-tropic HIV replication is observed at early stages of replication, requires signaling through inhibitory guanine nucleotide-binding regulatory (Gi) proteins, and is associated with increased cell surface colocalization of CD4 and the T-tropic HIV coreceptor CXCR4. These findings may further our understanding of the factors that influence the replication and spread of T-tropic strains of HIV in vivo and suggest that the use of cell signaling CC-chemokines as therapeutic agents for the purpose of limiting HIV replication in vivo should be approached with caution.

摘要

本研究表明，几种CC趋化因子，包括那些抑制HIV巨噬细胞嗜性毒株进入和复制的趋化因子，可增加CD4(+)T细胞中T细胞嗜性毒株的复制。在复制早期即可观察到T嗜性HIV复制增强，这需要通过抑制性鸟嘌呤核苷酸结合调节（Gi）蛋白进行信号传导，并且与CD4和T嗜性HIV共受体CXCR4在细胞表面的共定位增加有关。这些发现可能会加深我们对影响HIV T嗜性毒株在体内复制和传播因素的理解，并表明将细胞信号CC趋化因子用作体内限制HIV复制的治疗药物时应谨慎行事。