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[腹腔镜切除恶性肾上腺皮质瘤是否可行?腹腔镜切除术后早期、弥漫性和大量腹膜复发的病例报告]

[Is laparoscopic resection of a malignant corticoadrenaloma feasible? Case report of early, diffuse and massive peritoneal recurrence after attempted laparoscopic resection].

作者信息

Hamoir E, Meurisse M, Defechereux T

机构信息

Service de Chirurgie Endocrinienne et de Transplantation, Centre Hospitalier Universitaire, Liège, Belgique.

出版信息

Ann Chir. 1998;52(4):364-8.

PMID:9752471
Abstract

As surgeons wholeheartedly and intensely supporting (and deeply involved in) laparoscopic adrenal surgery, we think that laparoscopic resection of benign adrenal tumors is about to make conventional laparotomy obsolete. However, considering the many reported cases of tumor seeding after laparoscopy, we consider that proven or suspected adrenal cancer remains an absolute contra-indication for laparoscopy. It is precisely for this reason that we feel duty-bound to report the tragic and life-threatening case of a 25-year-old woman operated for malignant adrenal cancer and suffering from diffuse and massive peritoneal carcinomatosis diagnosed at the sixth postoperative month. A complete macroscopic debulking was carried out with removal of all visible tumor nodules followed by immediate intraperitoneal cisplatinum chemotherapy and six postoperative courses of systemic cisplatinum, etoposide and mitotane chemotherapy. This combined and aggressive therapy induced remission that perhaps could have been initially obtained with a more critical and proper surgical operation. We hope this paper will contribute in the future to avoiding similar catastrophes that could rapidly discredit such a promising new form of surgery.

摘要

作为全心全意且深度支持(并深度参与)腹腔镜肾上腺手术的外科医生,我们认为腹腔镜下切除良性肾上腺肿瘤即将使传统剖腹手术过时。然而,考虑到许多腹腔镜术后肿瘤种植的报道病例,我们认为已证实或疑似肾上腺癌仍然是腹腔镜手术的绝对禁忌证。正是出于这个原因,我们觉得有责任报告一例悲剧且危及生命的病例,一名25岁女性因恶性肾上腺癌接受手术,术后第六个月被诊断为弥漫性和广泛性腹膜癌转移。进行了彻底的肉眼下肿瘤减瘤术,切除了所有可见的肿瘤结节,随后立即进行腹腔内顺铂化疗以及术后六个疗程的全身顺铂、依托泊苷和米托坦化疗。这种联合且积极的治疗诱导了缓解,或许最初通过更严谨和恰当的手术操作就可以实现。我们希望本文将来能有助于避免类似的灾难,这些灾难可能会迅速使这种有前景的新手术形式声名扫地。

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[Is laparoscopic resection of a malignant corticoadrenaloma feasible? Case report of early, diffuse and massive peritoneal recurrence after attempted laparoscopic resection].[腹腔镜切除恶性肾上腺皮质瘤是否可行?腹腔镜切除术后早期、弥漫性和大量腹膜复发的病例报告]
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