Lam C M, Lo C M, Yuen W K, Liu C L, Fan S T
Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong.
Br J Surg. 1998 Sep;85(9):1198-200. doi: 10.1046/j.1365-2168.1998.00846.x.
Pulmonary metastasis is the commonest site of extrahepatic spread from hepatocellular carcinoma (HCC). The aim of the present study was to evaluate the efficacy of surgical management in patients with solitary pulmonary metastases from HCC.
This was a retrospective study of patients with HCC admitted for hepatectomy from July 1972 to June 1995. The records of patients who had a pulmonary resection for histologically proven pulmonary recurrence after curative hepatectomy were selected for analysis.
In the study interval, 380 patients with HCC underwent hepatectomy. Some 48 patients (12.6 per cent) developed pulmonary metastases documented pathologically or radiologically. Nine (seven men and two women) were suitable for curative pulmonary resection. The median disease-free survival between hepatectomy and appearance of the lung metastasis was 21 months. The median survival after pulmonary resection was 42 months, and the 1-, 2- and 5-year survival rates were 100, 78 and 67 per cent respectively.
Pulmonary resection for metastases from HCC resulted in long-term survival in these highly selected patients.
肺转移是肝细胞癌（HCC）肝外转移最常见的部位。本研究的目的是评估手术治疗HCC孤立性肺转移患者的疗效。
这是一项对1972年7月至1995年6月因肝癌行肝切除术的患者进行的回顾性研究。选择那些在根治性肝切除术后因组织学证实的肺复发而接受肺切除术的患者记录进行分析。
在研究期间，380例HCC患者接受了肝切除术。约48例（12.6%）出现经病理或影像学证实的肺转移。9例（7例男性和2例女性）适合进行根治性肺切除。肝切除至肺转移出现的无病生存期中位数为21个月。肺切除术后的生存期中位数为42个月，1年、2年和5年生存率分别为100%、78%和67%。
对HCC转移灶进行肺切除可使这些经过严格挑选的患者获得长期生存。
