冲洗液对大鼠股动脉的副作用。一项组织学和电子显微镜研究。

Side-effects of rinsing fluids on the rat femoral artery. A histological and electron microscopic study.

作者信息

Delaere O, Mennen U, Van Heerden W, Raubenheimer E, Wiese A M, Boomker D

机构信息

Department of Hand and Microsurgery, MEDUNSA, South Africa.

出版信息

J Hand Surg Br. 1997 Oct;22(5):568-73. doi: 10.1016/s0266-7681(97)80346-4.

DOI:10.1016/s0266-7681(97)80346-4

PMID:9752904

Abstract

Rinsing rat femoral arteries with various fluids in experimental conditions similar to those in clinical practice was found to have deleterious effects on the intimal and medial layers of the vessels. No statistically significant difference was found between the effects of Ringer's lactate and normal saline. Heparinized saline produced significantly less damage to the medial layer and less platelet cell deposition. Lignocaine 2% was found to be extremely damaging to the whole vessel wall, and highly thrombogenic. Nevertheless, all the arteries in each group remained patent 4 days after rinsing.

摘要

发现在与临床实践相似的实验条件下，用各种液体冲洗大鼠股动脉会对血管的内膜和中膜层产生有害影响。乳酸林格液和生理盐水的影响之间未发现统计学上的显著差异。肝素化盐水对中膜层的损伤明显较小，血小板细胞沉积也较少。发现2%的利多卡因对整个血管壁具有极大的损伤性，且具有高度血栓形成性。然而，每组中的所有动脉在冲洗后4天仍保持通畅。