Furuta G T, Wang Z S, Wershil B K
The Children's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.
Dig Dis Sci. 1998 Sep;43(9):2021-7. doi: 10.1023/a:1018851012940.
We determined whether neutrophil infiltration into the stomach wall occurred during systemic anaphylaxis in mice and assessed the participation of mast cells in the response. Normal mice sensitized and challenged with antigen exhibited significant neutrophil infiltration in the gastric mucosa and submucosa compared with saline-challenged mice. The development of clinical signs of anaphylaxis and extent of gastric neutrophil infiltration was similar in mast cell-deficient Kit(W)/Kit(W-v) or Mgf(Sl)/Mgf(Sl-d) mice and the respective normal congenic mice. Pretreatment with sodium cromoglycate prevented the clinical signs of anaphylaxis and significantly diminished the infiltration of neutrophils in +/+ or Kit(W)/Kit(W-v) mice. Systemic anaphylaxis is associated with neutrophil infiltration into the stomach wall in mice, and mast cells are not required for the development of either the clinical manifestations or gastric neutrophil infiltration observed in the response.
我们确定了在小鼠全身性过敏反应期间中性粒细胞是否浸润到胃壁，并评估了肥大细胞在该反应中的参与情况。与用盐水激发的小鼠相比，用抗原致敏并激发的正常小鼠在胃黏膜和黏膜下层表现出显著的中性粒细胞浸润。肥大细胞缺陷的Kit(W)/Kit(W-v)或Mgf(Sl)/Mgf(Sl-d)小鼠及其各自的正常同基因小鼠在过敏反应临床症状的发展和胃中性粒细胞浸润程度方面相似。色甘酸钠预处理可预防过敏反应的临床症状，并显著减少+/+或Kit(W)/Kit(W-v)小鼠中性粒细胞的浸润。全身性过敏反应与小鼠胃壁中性粒细胞浸润有关，在该反应中观察到的临床表现或胃中性粒细胞浸润的发展不需要肥大细胞。
