Vermette P, Thibault J, Laroche G
Quebec Biomaterials Institute, Centre Hospitalier Universitaire de Québec, Canada.
Artif Organs. 1998 Sep;22(9):746-52. doi: 10.1046/j.1525-1594.1998.06103.x.
The design of a nonpulsatile and pulsatile system using a centrifugal pump is presented. To induce a pulsatile flow with a centrifugal pump, an independent pneumatically driven unit provided flow patterns over a wide range of frequencies and amplitudes. The pulsatile flow was generated by the axial displacement of a cylinder that periodically compressed the flexible conduit that is connected to the pump. The system can accommodate flow rates up to 6,000 ml/min and transmural pressures up to 500 mm Hg and is capable of maintaining the pressure at a constant value. This circuit produced reproducible pressure waves having a frequency up to 4 Hz. The periodicity of the transmural pressure between 80 and 180 mm Hg was similar to the pressure wave propagation observed in peripheral circulation. Capable of adequately reproducing continuous and pulsatile flow, the apparatus is therefore versatile to allow in vitro evaluation of cardiovascular devices.
本文介绍了一种使用离心泵的非搏动性和搏动性系统的设计。为了用离心泵产生搏动性血流，一个独立的气动驱动单元提供了广泛频率和幅度范围内的血流模式。搏动性血流是由一个圆柱体的轴向位移产生的，该圆柱体周期性地压缩连接到泵的柔性导管。该系统能够适应高达6000毫升/分钟的流速和高达500毫米汞柱的跨壁压力，并能够将压力维持在恒定值。该回路产生了频率高达4赫兹的可重复压力波。80至180毫米汞柱之间的跨壁压力周期性与外周循环中观察到的压力波传播相似。该装置能够充分再现连续和搏动性血流，因此具有通用性，可用于体外评估心血管装置。
