Yang C Y, Chang C S, Chen G H
Dept. of Internal Medicine, Taichung Veterans General Hospital, Taiwan.
Scand J Gastroenterol. 1998 Aug;33(8):867-71. doi: 10.1080/00365529850171549.
Small-intestinal bacterial overgrowth (SIBO) has been considered a predisposing factor of spontaneous bacterial peritonitis in cirrhotic patients by bacterial translocation or hematogenous spread during spontaneous bacteremia. We investigated 45 cirrhotic patients and 28 healthy subjects to assess the prevalence of SIBO and its relationship with the severity of liver dysfunction and the presence of ascites.
Bacterial overgrowth was measured by the glucose hydrogen and methane breath test.
SIBO was documented in 16 (35.6%) of the 45 cirrhotic patients and in 1 (3.6%) of the 28 healthy controls. The prevalence of SIBO was significantly higher in patients with Child-Pugh class B or C (50%) than in those with class A (19%) and had no relationship with the presence or absence of ascites.
We conclude that the prevalence of SIBO in cirrhotic patients is approximately 35.6% and that it is related to the severity of liver disease. There was no difference among various causes of cirrhosis, such as viral, alcoholic, or idiopathic.
小肠细菌过度生长（SIBO）被认为是肝硬化患者自发性细菌性腹膜炎的一个易感因素，其通过细菌移位或在自发性菌血症期间的血行播散导致该病。我们对45例肝硬化患者和28名健康受试者进行了调查，以评估SIBO的患病率及其与肝功能障碍严重程度和腹水存在情况的关系。
通过葡萄糖氢和甲烷呼气试验测量细菌过度生长情况。
45例肝硬化患者中有16例（35.6%）检测出SIBO，28名健康对照者中有1例（3.6%）检测出SIBO。Child-Pugh B级或C级患者中SIBO的患病率（50%）显著高于A级患者（19%），且与腹水的有无无关。
我们得出结论，肝硬化患者中SIBO的患病率约为35.6%，且与肝脏疾病的严重程度相关。在不同病因的肝硬化患者中，如病毒性、酒精性或特发性肝硬化患者之间，SIBO患病率无差异。
