Romero-Gómez M, Suárez-García E, Otero M A, Rufo M C, Castilla L, Guerrero P, López-Garrido J, Larraona J L, Fernández M C
Digestive Diseases Unit, Hospital Universitario de Valme, Sevilla, Spain.
J Clin Gastroenterol. 1998 Sep;27(2):162-5. doi: 10.1097/00004836-199809000-00016.
We report a patient in whom sarcoidosis coexisted with sclerosing cholangitis and chronic atrophic autoimmune gastritis. There are some autoimmune diseases associated with primary sclerosing cholangitis; the difference between sarcoidosis and all other autoimmune diseases associated with primary sclerosing cholangitis is the ability of the former to damage the biliary tree. Moreover, when sarcoidosis behaves like cholestasis it can damage the biliary tree, mimicking primary sclerosing cholangitis, with high immunoglobulin M but without inflammatory bowel disease and p-ANCAs negative. We believe that it should be regarded as a single disease "infiltrative sclerosing cholangitis" because this is not a primary disease and sarcoidosis would be responsible for a beaded biliary tree.
我们报告了一名结节病与硬化性胆管炎及慢性萎缩性自身免疫性胃炎共存的患者。有一些自身免疫性疾病与原发性硬化性胆管炎相关；结节病与所有其他与原发性硬化性胆管炎相关的自身免疫性疾病的不同之处在于，前者有损害胆管树的能力。此外，当结节病表现为胆汁淤积时，它会损害胆管树，酷似原发性硬化性胆管炎，免疫球蛋白M升高，但无炎症性肠病且抗中性粒细胞胞浆抗体阴性。我们认为应将其视为一种单一疾病“浸润性硬化性胆管炎”，因为这并非原发性疾病，结节病是造成胆管树串珠样改变的原因。
