异丙肾上腺素对急性分离的大鼠杏仁核神经元中N-甲基-D-天冬氨酸电流的增强作用。
Potentiation of N-methyl-D-aspartate currents by isoproterenol in the acutely dissociated rat amygdalar neurons.
作者信息
Huang C C, Lin C H, Gean P W
机构信息
Department of Pharmacology, College of Medicine, National Cheng-Kung University, Tainan City, Taiwan.
出版信息
Neurosci Lett. 1998 Aug 28;253(1):9-12. doi: 10.1016/s0304-3940(98)00571-0.
Whole-cell patch-clamp recordings in the acutely dissociated amygdalar neurons were performed to investigate the effect of isoproterenol (Iso) on NMDA currents. Bath application of Iso selectively enhanced the NMDA currents without affecting the AMPA currents. Iso potentiated the NMDA currents to the same extent at various holding potentials and the reversal potential for the NMDA response was not altered. These results suggest that adrenergic innvervations in this area may play an important role in synaptic plasticity.
采用急性分离的杏仁核神经元进行全细胞膜片钳记录，以研究异丙肾上腺素（Iso）对N-甲基-D-天冬氨酸（NMDA）电流的影响。浴槽给药Iso可选择性增强NMDA电流，而不影响α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）电流。在不同的钳制电位下，Iso增强NMDA电流的程度相同，且NMDA反应的反转电位未改变。这些结果表明，该区域的肾上腺素能神经支配可能在突触可塑性中起重要作用。
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