Hukin J, Epstein F, Lefton D, Allen J
Department of Neurology, Beth Israel Medical Center, New York, N.Y., USA.
Pediatr Neurosurg. 1998 Jul;29(1):40-5. doi: 10.1159/000028683.
This study aimed to determine the safety of deferring radiotherapy in pediatric intracranial ependymoma following a radiographically confirmed gross total resection in patients with localized disease.
Children over age 3 were recruited prospectively from 1990 to 1997, following a surgical impression and radiologic confirmation of a gross total resection of an intracranial ependymoma.
10/32 cases of intracranial ependymomas were both eligible and gave consent. 7 remain free of disease without further intervention. 3 recurred, 2 were salvaged with surgery and radiotherapy, none died.
Deferral of radiotherapy following gross total resection alone is a safe option in supratentorial ependymomas. The pattern of recurrence is usually local and patients may be salvaged with additional surgery with or without radiotherapy.
本研究旨在确定对于局限性疾病且经影像学证实为大体全切的小儿颅内室管膜瘤患者，推迟放疗的安全性。
1990年至1997年，前瞻性招募3岁以上儿童，这些儿童经手术判断及影像学确认颅内室管膜瘤已大体全切。
32例颅内室管膜瘤患者中，10例符合条件并同意参与研究。7例未进行进一步干预，仍无疾病复发。3例复发，2例通过手术及放疗挽救，无一例死亡。
对于幕上室管膜瘤，仅在大体全切后推迟放疗是一种安全的选择。复发模式通常为局部复发，患者可通过再次手术（无论是否联合放疗）挽救。
