van Ballegooijen M, Beck S, Boon M E, Boer R, Habbema J D
Department of Public Health, Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands.
Acta Cytol. 1998 Sep-Oct;42(5):1133-8. doi: 10.1159/000332101.
To study the rescreen and PAPNET effects on enriched material derived from smears screened routinely using PAPNET and conventional microscopy.
A series of 432 smears (containing 122 atypical squamous cells of undetermined significance [ASCUS] plus 44 at least dysplastic squamous intraepithelial lesion-positive [SIL+] ones), screened routinely with the conventional method, were rescreened using the PAPNET system. Another series of 461 smears (containing 140 ASCUS + 52 SIL+ ones) screened routinely with PAPNET were rescreened conventionally. The rescreen effect, defined as the effect of differences between the rescreen and routine screening situation, was investigated by comparing the rescreen results in both series of smears with the routine results in both series. The effect of using either method of screening was studied by comparing the PAPNET results in both series with the results of conventional screening in both series.
The rescreen effect was statistically significant both for a higher number of smears classified as negative (less than ASCUS) and a higher number of smears classified as high grade SIL or more. PAPNET-assisted screening resulted in a significantly higher number of smears classified as high grade SIL+, although for this latter finding there is an unexplained significant difference between conventional and PAPNET-screened cases in the changes made by the cytopathologist in the cytotechnologists' diagnoses.
The rescreen effect should not be ignored when enriched material is used.
研究重新筛查及PAPNET系统对采用PAPNET系统和传统显微镜技术进行常规筛查的涂片富集样本的影响。
采用传统方法对一系列432份涂片（包含122例意义不明确的非典型鳞状细胞[ASCUS]加44例至少为发育异常的鳞状上皮内病变阳性[SIL+]涂片）进行常规筛查后，再用PAPNET系统进行重新筛查。对另一系列461份采用PAPNET系统进行常规筛查的涂片（包含140例ASCUS + 52例SIL+涂片）进行传统方法重新筛查。通过比较两系列涂片的重新筛查结果与常规筛查结果，研究重新筛查效果，即重新筛查与常规筛查情况之间差异的影响。通过比较两系列PAPNET结果与两系列传统筛查结果，研究采用两种筛查方法的效果。
对于更多分类为阴性（低于ASCUS）的涂片以及更多分类为高级别SIL或更高级别的涂片，重新筛查效果具有统计学意义。PAPNET辅助筛查导致分类为高级别SIL+的涂片数量显著增加，尽管对于后一结果，细胞病理学家对细胞技术员诊断结果的改变在传统筛查和PAPNET筛查病例之间存在无法解释的显著差异。
使用富集样本时，重新筛查效果不容忽视。
