结构多样的小分子化合物的分配与Caco-2细胞通透性的相关性 - Suppr

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超能文献

Correlating partitioning and caco-2 cell permeability of structurally diverse small molecular weight compounds.

作者信息

Yazdanian M, Glynn S L, Wright J L, Hawi A

机构信息

Department of Pharmaceutics, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut 06877, USA.

出版信息

Pharm Res. 1998 Sep;15(9):1490-4. doi: 10.1023/a:1011930411574.

DOI:10.1023/a:1011930411574

PMID:9755906

Abstract

摘要

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Correlating partitioning and caco-2 cell permeability of structurally diverse small molecular weight compounds.结构多样的小分子化合物的分配与Caco-2细胞通透性的相关性

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Caco-2 monolayers in experimental and theoretical predictions of drug transport.Caco-2单层细胞在药物转运的实验和理论预测中。

Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):27-43. doi: 10.1016/s0169-409x(00)00128-9.

Polar molecular surface properties predict the intestinal absorption of drugs in humans.极性分子表面性质可预测药物在人体中的肠道吸收。

Pharm Res. 1997 May;14(5):568-71. doi: 10.1023/a:1012188625088.

Correlation of drug absorption with molecular surface properties.药物吸收与分子表面性质的相关性。

J Pharm Sci. 1996 Jan;85(1):32-9. doi: 10.1021/js950285r.

Comparison of the permeability characteristics of a human colonic epithelial (Caco-2) cell line to colon of rabbit, monkey, and dog intestine and human drug absorption.人结肠上皮（Caco-2）细胞系与兔、猴和犬肠道结肠的通透性特征比较及人体药物吸收情况

Pharm Res. 1993 Jan;10(1):113-8. doi: 10.1023/a:1018937416447.

A correlation between the permeability characteristics of a series of peptides using an in vitro cell culture model (Caco-2) and those using an in situ perfused rat ileum model of the intestinal mucosa.使用体外细胞培养模型（Caco-2）和使用肠道黏膜原位灌注大鼠回肠模型得到的一系列肽的渗透性特征之间的相关性。

Pharm Res. 1993 Dec;10(12):1710-4. doi: 10.1023/a:1018961828510.

Molecular dynamics simulations of a lipid bilayer and of hexadecane: an investigation of membrane fluidity.脂质双层和十六烷的分子动力学模拟：膜流动性研究

Science. 1993 Oct 8;262(5131):223-6. doi: 10.1126/science.8211140.

High lipophilicity decreases drug transport across intestinal epithelial cells.高亲脂性会降低药物跨肠上皮细胞的转运。

J Pharmacol Exp Ther. 1994 May;269(2):654-8.

IAM chromatography: an in vitro screen for predicting drug membrane permeability.离子交换吸附色谱法：一种预测药物膜通透性的体外筛选方法。

J Med Chem. 1995 Feb 17;38(4):590-4. doi: 10.1021/jm00004a004.

Drug delivery studies in Caco-2 monolayers. Synthesis, hydrolysis, and transport of O-cyclopropane carboxylic acid ester prodrugs of various beta-blocking agents.Caco-2单层细胞中的药物递送研究。各种β-受体阻滞剂的O-环丙烷羧酸酯前药的合成、水解及转运

Pharm Res. 1995 Mar;12(3):387-92. doi: 10.1023/a:1016204602471.

Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans.多种体外和原位模型中测定的肠道通透性比较：与人体吸收的关系。

Pharm Res. 1995 May;12(5):693-9. doi: 10.1023/a:1016207525186.

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