结构多样的小分子化合物的分配与Caco-2细胞通透性的相关性 - Suppr

Suppr

超能文献

Correlating partitioning and caco-2 cell permeability of structurally diverse small molecular weight compounds.

作者信息

Yazdanian M, Glynn S L, Wright J L, Hawi A

机构信息

Department of Pharmaceutics, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut 06877, USA.

出版信息

Pharm Res. 1998 Sep;15(9):1490-4. doi: 10.1023/a:1011930411574.

DOI:10.1023/a:1011930411574

PMID:9755906

Abstract

摘要

相似文献

Correlating partitioning and caco-2 cell permeability of structurally diverse small molecular weight compounds.结构多样的小分子化合物的分配与Caco-2细胞通透性的相关性

Pharm Res. 1998 Sep;15(9):1490-4. doi: 10.1023/a:1011930411574.

Modeling Caco-2 permeability of drugs using immobilized artificial membrane chromatography and physicochemical descriptors.使用固定化人工膜色谱法和物理化学描述符模拟药物的Caco-2渗透性。

J Chromatogr A. 2005 Apr 29;1072(2):159-68. doi: 10.1016/j.chroma.2005.03.006.

Physicochemical determinants of passive membrane permeability: role of solute hydrogen-bonding potential and volume.被动膜通透性的物理化学决定因素：溶质氢键潜力和体积的作用。

J Med Chem. 2001 Oct 25;44(22):3721-9. doi: 10.1021/jm010253i.

Evaluation of cytotoxicity of surfactants used in self-micro emulsifying drug delivery systems and their effects on paracellular transport in Caco-2 cell monolayer.评价自微乳药物传递系统中所用表面活性剂的细胞毒性及其对 Caco-2 细胞单层细胞旁通透性的影响。

Eur J Pharm Sci. 2012 Oct 9;47(3):564-73. doi: 10.1016/j.ejps.2012.07.005. Epub 2012 Jul 27.

Prediction of Caco-2 cell permeability using partial least squares multivariate analysis.使用偏最小二乘多元分析预测Caco-2细胞通透性。

Pharmazie. 2001 May;56(5):407-11.

[Study of the effect of surface-active agents on living cells, used as component parts in microemulsions, based on their chemical structures and critical micelle-formative concentration (CMC)].基于表面活性剂的化学结构和临界胶束形成浓度（CMC），研究其作为微乳液组成部分对活细胞的影响

Acta Pharm Hung. 2013;83(1):3-11.

Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight.利用药物的亲脂性和分子量，通过Caco-2细胞单层的被动扩散来估算通透性。

Eur J Pharm Sci. 1998 Oct;6(4):317-24.

ADME evaluation in drug discovery. 5. Correlation of Caco-2 permeation with simple molecular properties.药物发现中的ADME评估。5. Caco-2细胞通透性与简单分子性质的相关性。

J Chem Inf Comput Sci. 2004 Sep-Oct;44(5):1585-600. doi: 10.1021/ci049884m.

Theoretical calculation and prediction of Caco-2 cell permeability using MolSurf parametrization and PLS statistics.使用分子表面参数化和偏最小二乘法统计对Caco-2细胞通透性进行理论计算和预测。

Pharm Res. 1997 Dec;14(12):1786-91. doi: 10.1023/a:1012196216736.

Evaluation of an accelerated Caco-2 cell permeability model.加速的Caco-2细胞通透性模型的评估

J Pharm Sci. 2000 Mar;89(3):336-45. doi: 10.1002/(SICI)1520-6017(200003)89:3<336::AID-JPS5>3.0.CO;2-M.

引用本文的文献

Identification of Potential Pteridin Reductase-1 Inhibitors for the Treatment of Leishmaniasis: A Bioinformatics Approach.鉴定用于治疗利什曼病的潜在蝶啶还原酶-1抑制剂：一种生物信息学方法。

Pharmaceuticals (Basel). 2025 Aug 21;18(8):1237. doi: 10.3390/ph18081237.

Combating oxi-inflamm-aging: Passerini adducts tethered with 1,2,3-triazoles for enhanced antioxidant defense and 5-LOX inhibition.对抗氧化应激炎症衰老：与1,2,3-三唑相连的帕瑟里尼加合物可增强抗氧化防御并抑制5-脂氧合酶

RSC Med Chem. 2025 Apr 14. doi: 10.1039/d4md00981a.

Quantitative in vitro-to-in vivo extrapolation of human adrenergic and trace amine-associated receptor 1 potencies of pre-workout supplement ingredients using physiologically based kinetic modelling-based reverse dosimetry.使用基于生理药代动力学模型的反向剂量测定法对运动前补充剂成分的人肾上腺素能和痕量胺相关受体1效价进行体外到体内的定量外推。

Arch Toxicol. 2025 May;99(5):1999-2021. doi: 10.1007/s00204-025-03992-7. Epub 2025 Apr 3.

In Vitro and In Vivo Pharmacokinetic Characterization of 7-Hydroxymitragynine, an Active Metabolite of Mitragynine, in Sprague-Dawley Rats.7-羟基帽柱木碱（帽柱木碱的一种活性代谢产物）在斯普拉格-道利大鼠体内和体外的药代动力学特征

Eur J Drug Metab Pharmacokinet. 2025 May;50(3):205-218. doi: 10.1007/s13318-025-00939-2. Epub 2025 Mar 22.

Exploring novel inhibitors for Babesia bigemina lactate dehydrogenase: a computational structural biology perspective.从计算结构生物学角度探索双芽巴贝斯虫乳酸脱氢酶的新型抑制剂

Parasitol Res. 2025 Jan 7;124(1):1. doi: 10.1007/s00436-024-08433-5.

Structure optimization and molecular dynamics studies of new tumor-selective -triazines targeting DNA and MMP-10/13 for halting colorectal and secondary liver cancers.新型肿瘤选择性 - 三嗪类化合物的结构优化及针对 DNA 和 MMP-10/13 的分子动力学研究，用于阻断结直肠癌和继发性肝癌。

J Enzyme Inhib Med Chem. 2024 Dec;39(1):2423174. doi: 10.1080/14756366.2024.2423174. Epub 2024 Nov 8.

Updating the Pharmacological Effects of α-Mangostin Compound and Unraveling Its Mechanism of Action: A Computational Study Review.更新 α-倒捻子素化合物的药理作用及其作用机制的研究进展：计算研究综述。

Drug Des Devel Ther. 2024 Oct 24;18:4723-4748. doi: 10.2147/DDDT.S478388. eCollection 2024.

Novel curcumin-based analogues as potential VEGFR2 inhibitors with promising metallic loading nanoparticles: synthesis, biological evaluation, and molecular modelling investigation.新型姜黄素类类似物作为具有前景的载金属纳米颗粒的潜在VEGFR2抑制剂：合成、生物学评价及分子模拟研究

RSC Med Chem. 2024 Sep 27;15(12):4039-67. doi: 10.1039/d4md00574k.

Improving the Accuracy of Permeability Data to Gain Predictive Power: Assessing Sources of Variability in Assays Using Cell Monolayers.提高渗透率数据的准确性以获得预测能力：评估使用细胞单层进行的实验中的变异性来源。

Membranes (Basel). 2024 Jul 14;14(7):157. doi: 10.3390/membranes14070157.

Dual active pyrimidine-based carbocyclic nucleoside derivatives: synthesis, and and anti-diabetic and anti-microbial studies.基于双活性嘧啶的碳环核苷衍生物：合成以及抗糖尿病和抗菌研究。

RSC Adv. 2024 Mar 21;14(14):9559-9569. doi: 10.1039/d4ra00304g. eCollection 2024 Mar 20.

本文引用的文献

Caco-2 monolayers in experimental and theoretical predictions of drug transport.Caco-2单层细胞在药物转运的实验和理论预测中。

Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):27-43. doi: 10.1016/s0169-409x(00)00128-9.

Polar molecular surface properties predict the intestinal absorption of drugs in humans.极性分子表面性质可预测药物在人体中的肠道吸收。

Pharm Res. 1997 May;14(5):568-71. doi: 10.1023/a:1012188625088.

Correlation of drug absorption with molecular surface properties.药物吸收与分子表面性质的相关性。

J Pharm Sci. 1996 Jan;85(1):32-9. doi: 10.1021/js950285r.

Comparison of the permeability characteristics of a human colonic epithelial (Caco-2) cell line to colon of rabbit, monkey, and dog intestine and human drug absorption.人结肠上皮（Caco-2）细胞系与兔、猴和犬肠道结肠的通透性特征比较及人体药物吸收情况

Pharm Res. 1993 Jan;10(1):113-8. doi: 10.1023/a:1018937416447.

A correlation between the permeability characteristics of a series of peptides using an in vitro cell culture model (Caco-2) and those using an in situ perfused rat ileum model of the intestinal mucosa.使用体外细胞培养模型（Caco-2）和使用肠道黏膜原位灌注大鼠回肠模型得到的一系列肽的渗透性特征之间的相关性。

Pharm Res. 1993 Dec;10(12):1710-4. doi: 10.1023/a:1018961828510.

Molecular dynamics simulations of a lipid bilayer and of hexadecane: an investigation of membrane fluidity.脂质双层和十六烷的分子动力学模拟：膜流动性研究

Science. 1993 Oct 8;262(5131):223-6. doi: 10.1126/science.8211140.

High lipophilicity decreases drug transport across intestinal epithelial cells.高亲脂性会降低药物跨肠上皮细胞的转运。

J Pharmacol Exp Ther. 1994 May;269(2):654-8.

IAM chromatography: an in vitro screen for predicting drug membrane permeability.离子交换吸附色谱法：一种预测药物膜通透性的体外筛选方法。

J Med Chem. 1995 Feb 17;38(4):590-4. doi: 10.1021/jm00004a004.

Drug delivery studies in Caco-2 monolayers. Synthesis, hydrolysis, and transport of O-cyclopropane carboxylic acid ester prodrugs of various beta-blocking agents.Caco-2单层细胞中的药物递送研究。各种β-受体阻滞剂的O-环丙烷羧酸酯前药的合成、水解及转运

Pharm Res. 1995 Mar;12(3):387-92. doi: 10.1023/a:1016204602471.

Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans.多种体外和原位模型中测定的肠道通透性比较：与人体吸收的关系。

Pharm Res. 1995 May;12(5):693-9. doi: 10.1023/a:1016207525186.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验