Ray M, Kumar L, Prasad R
Department of Paediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Int J Tuberc Lung Dis. 1998 Sep;2(9):719-25.
Department of Paediatrics and Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
To assess the plasma zinc status in children with tuberculosis and to correlate it with nutritional status, activity and severity of disease in relation to antituberculosis therapy.
The plasma zinc status of 50 children with different forms of tuberculosis was compared with 10 healthy and 10 malnourished children without tuberculosis at 0, 1, 2, 3 and 6 months of antituberculosis therapy.
The mean plasma zinc concentration in children with pulmonary tuberculosis (n = 20) was 68.65+/-2.50 microg/dl, central nervous system (CNS) tuberculosis (n = 10) was 64.20+/-3.82 microg/dl, tuberculous lymphadenitis (n = 10) was 63.2+/-3.77 microg/dl and disseminated tuberculosis (n = 10) was 59.0+/-2.75 microg/dl at 0 months. The mean plasma zinc level of healthy children was 129.10+/-3.01 microg/dl and in malnourished non-tuberculous children it was 108.40+/-3.16 microg/dl. Thus children with tuberculosis had significantly lower plasma zinc level than those without tuberculosis, irrespective of their nutritional status (P < 0.001). There was a significant rise in zinc level at the end of 6 months of antituberculosis therapy (P < 0.001).
Plasma zinc status may prove to be a good objective marker for monitoring the severity of the disease and the response to therapy.
印度昌迪加尔医学教育与研究研究生院儿科学与生物化学系。
评估结核病患儿的血浆锌水平，并将其与营养状况、疾病活动度及抗结核治疗相关的疾病严重程度进行关联分析。
对50例不同类型结核病患儿在抗结核治疗的0、1、2、3和6个月时的血浆锌水平，与10例健康且无结核病的儿童以及10例营养不良且无结核病的儿童进行比较。
在0个月时，肺结核患儿（n = 20）的平均血浆锌浓度为68.65±2.50微克/分升，中枢神经系统（CNS）结核患儿（n = 10）为64.20±3.82微克/分升，结核性淋巴结炎患儿（n = 10）为63.2±3.77微克/分升，播散性结核病患儿（n = 10）为59.0±2.75微克/分升。健康儿童的平均血浆锌水平为129.10±3.01微克/分升，营养不良且无结核病的儿童为108.40±3.16微克/分升。因此，无论营养状况如何，结核病患儿的血浆锌水平均显著低于无结核病的儿童（P < 0.001）。抗结核治疗6个月结束时锌水平有显著升高（P < 0.001）。
血浆锌水平可能是监测疾病严重程度及治疗反应的良好客观指标。
