Mohan G, Kulshreshtha S, Sharma P
Department of Pharmacology, SN Medical College, Agra-282002, India.
Biol Trace Elem Res. 2006 Summer;111(1-3):63-9. doi: 10.1385/BTER:111:1:63.
The effectiveness and success of antitubercular therapy is mainly measured by identifying the organism in sputum. In certain patients, especially in geriatric patients, available tuberculosis tests are not satisfactory and do not provide enough information on the effectiveness of antitubercular therapy, as the symptoms might be confused with the existing symptoms of ongoing diseases. Therefore, 60 diagnosed and randomly selected patients with tuberculosis were included into this study. The patients with other associated diseases likely to influence serum copper and zinc were not included in the study. The estimations of serum copper and zinc were done in healthy volunteers and in tubercular patients before the start of treatment and after 4 wk of antitubercular treatment. The average plasma concentration of serum copper and zinc in healthy volunteers were 102 +/- 20 microg/dL and 96 +/- 18 microg/dL respectively. In tuberculosis patients, serum copper and zinc levels were 123.65 +/- 9.98 microg/dL and 64.14 +/- 3.97 microg/dL, respectively, before the start of treatment, which came down to 116.23 +/- 4.27 mug/dL and 74.31 +/- 3.60 microg/dL, respectively, after 4 wk of antitubercular treatment.
抗结核治疗的有效性和成功主要通过在痰液中鉴定病原体来衡量。在某些患者中，尤其是老年患者，现有的结核病检测并不令人满意，无法提供足够的关于抗结核治疗有效性的信息，因为症状可能与现有疾病的症状相混淆。因此，本研究纳入了60例经诊断并随机选取的结核病患者。可能影响血清铜和锌的其他相关疾病患者未纳入本研究。在健康志愿者和结核病患者开始治疗前及抗结核治疗4周后进行血清铜和锌的测定。健康志愿者血清铜和锌的平均血浆浓度分别为102±20μg/dL和96±18μg/dL。在结核病患者中，治疗开始前血清铜和锌水平分别为123.65±9.98μg/dL和64.14±3.97μg/dL，抗结核治疗4周后分别降至116.23±4.27μg/dL和74.31±3.60μg/dL。
