Zidek Z, Masek K
Institute of Pharmacology, Academy of Sciences of the Czech Republic, Prague.
Int J Immunopharmacol. 1998 Jul;20(7):319-43. doi: 10.1016/s0192-0561(98)00036-8.
The literature data assembled in this article document the variation of immunobiological effects of nitric oxide (NO). A number of factors are obviously responsible for the diversity, ranging from inactivity, alleviation, but not rarely to exacerbation of certain pathogenetic processes. A better understanding of NO interactions with the immune system can only be reached if more complex experimental designs to study the effects of reactive nitrogen species are adopted in the future. They should integrate major participating variables and take into account pharmacodynamic/kinetic aspects of NO production in triggering the ultimate effects. If manipulation of NO in the organism by means of recently developed NO inhibitors and NO donors is to become a rational tool of immunopharmacological strategies, detailed knowledge of their pharmacologies and toxicologies is urgently needed in order to differentiate between the effects of NO and other side effects. Hopefully, this approach could improve the predictability of the clinical outcomes of NO manipulation.
本文汇总的文献数据记录了一氧化氮（NO）免疫生物学效应的变化。许多因素显然导致了这种多样性，范围从无活性、缓解作用，但也不乏某些致病过程的加剧。只有在未来采用更复杂的实验设计来研究活性氮物质的作用，才能更好地理解NO与免疫系统的相互作用。这些设计应整合主要参与变量，并考虑NO产生在引发最终效应时的药效学/动力学方面。如果通过最近开发的NO抑制剂和NO供体在生物体中对NO进行操控要成为免疫药理学策略的合理工具，那么迫切需要详细了解它们的药理学和毒理学，以便区分NO的作用和其他副作用。希望这种方法能够提高对NO操控临床结果的可预测性。
