Aschengrau A, Hardy S, Mackey P, Pultinas D
Department of Epidemiology and Biostatistics, Boston University School of Public Health, Massachusetts, USA.
Environ Res. 1998 Oct;79(1):41-50. doi: 10.1006/enrs.1998.3858.
This prospective environmental intervention study was conducted to determine the impact of low-technology lead hazard reduction activities among children with mildly elevated blood lead levels. Children whose homes had severe lead hazards were automatically assigned to the intervention group. Children whose homes had lesser hazards were randomly assigned to the intervention group or comparison group. The one-time intervention focused mainly on cleaning and repainting window areas and educating caregivers to maintain effective housekeeping techniques. Changes in blood lead and dust lead loading levels were observed following the interventions. Analysis of covariance was used to adjust comparisons of postintervention levels for preintervention levels and other variables. The lead hazard reduction activities were associated with a modest decline in blood lead levels among children with severe hazards. The magnitude of the decline depended on the confounder that was controlled; the majority ranged from-1.1. to-1.6 microgram/dL. A moderate reduction in window well dust lead loading levels was also observed. While low-technology lead hazard reduction measures appeared to be an effective secondary prevention strategy among children with severe household lead hazards, larger studies are needed to confirm these results.
这项前瞻性环境干预研究旨在确定低技术铅危害降低活动对血铅水平轻度升高儿童的影响。家中铅危害严重的儿童被自动分配到干预组。家中铅危害较小的儿童被随机分配到干预组或对照组。一次性干预主要集中在清洁和重新粉刷窗户区域,并教育照顾者保持有效的家政技巧。干预后观察血铅和灰尘铅负荷水平的变化。协方差分析用于调整干预后水平与干预前水平及其他变量的比较。铅危害降低活动与严重危害儿童的血铅水平适度下降有关。下降幅度取决于所控制的混杂因素;大多数范围在-1.1至-1.6微克/分升之间。还观察到窗户井灰尘铅负荷水平有适度降低。虽然低技术铅危害降低措施似乎是对家庭铅危害严重儿童有效的二级预防策略,但需要更大规模的研究来证实这些结果。