Eneström S, Vavruch L, Frånlund B, Nordenskjöld B
Department of Pathology, University Hospital, Linköping, Sweden.
Neurochirurgie. 1998 Mar;44(1):25-30.
Histological grading is widely used to evaluate the prognosis for patients with astrocytic tumors. Many complimentary methods have been introduced, such as proliferation markers in order to better assess the proliferative potential of these gliomas.
Archival, paraffin embedded specimens of recurrent astrocytic tumors of varying grades from 22 patients were examined using antibodies against Ki-67 (MIB-1). Labeling indices (LI) were analyzed at the first and second operations and compared with tumor grades, age of the patients and the time between the operations as well as the survival time.
There was a progression of malignancy between the operations. Dividing Ki-67 labeling indices in < or = 10% vs. > 10% significantly separated parameters such as the time between the first operation and relapse as well as the cumulative proportion of survival. The proliferation fraction was an independent prognostic factor.
Assessment of Ki-67 LI is highly recommended in addition to histology in evaluation of the malignancy potential of astrocytic tumors.
组织学分级广泛用于评估星形细胞瘤患者的预后。已引入许多辅助方法，如增殖标志物，以便更好地评估这些胶质瘤的增殖潜能。
使用抗Ki-67（MIB-1）抗体对22例不同分级的复发性星形细胞瘤石蜡包埋存档标本进行检测。分析首次和第二次手术时的标记指数（LI），并与肿瘤分级、患者年龄、手术间隔时间以及生存时间进行比较。
两次手术之间存在恶性进展。将Ki-67标记指数分为≤10%和>10%，可显著区分首次手术与复发之间的时间以及累积生存比例等参数。增殖分数是一个独立的预后因素。
在评估星形细胞瘤的恶性潜能时，除了组织学检查外，强烈建议评估Ki-67 LI。
