Ekborg-Ott K H, Kullman J P, Wang X, Gahm K, He L, Armstrong D W
Department of Chemistry, University of Missouri-Rolla 65404-0249, USA.
Chirality. 1998;10(7):627-60. doi: 10.1002/(SICI)1520-636X(1998)10:7<627::AID-CHIR10>3.0.CO;2-1.
Avoparcin is a macrocyclic glycopeptide antibiotic structurally related to vancomycin, teicoplanin, and ristocetin A. When attached to 5-microns spherical silica gel, the avoparcin proved to be an effective chiral stationary phase (CSP) that could be used in the reversed-phase, normal-phase, and polar-organic modes. The avoparcin CSP was complimentary to the other macrocyclic glycopeptide CSPs in that it could resolve some racemates that the others could not, and vice versa. Some important compounds resolved on the avoparcin CSP include verapamil, thyroxine, mephenytoin, and 2-imidazolidone-4-carboxylic acid. The use of this CSP and the optimization of separations on it are discussed. Avoparcin appears to be a useful addition to this family of CSPs.
阿伏巴星是一种大环糖肽类抗生素，在结构上与万古霉素、替考拉宁和瑞斯托菌素A相关。当连接到5微米的球形硅胶上时，阿伏巴星被证明是一种有效的手性固定相（CSP），可用于反相、正相和极性有机模式。阿伏巴星CSP与其他大环糖肽类CSP互补，因为它可以拆分一些其他CSP无法拆分的外消旋体，反之亦然。在阿伏巴星CSP上拆分的一些重要化合物包括维拉帕米、甲状腺素、美芬妥因和2-咪唑烷酮-4-羧酸。本文讨论了该CSP的使用及其分离条件的优化。阿伏巴星似乎是这类CSP的一个有用补充。
