Büchner S A
Dermatologische Universitätsklinik, Kantonsspital Basel.
Ther Umsch. 1998 Aug;55(8):503-8.
Onchomycosis is the most common nail disease, accounting for approximately 30% of all cutaneous fungal infections. The treatment approach needs to take into account the location and extent of onychomycosis, sensitivity of drug to fungal organism, adverse-effects profile, dosage schedule, duration of therapy, concomitant medical conditions, and concurrent medications. To confirm the diagnosis, it is important to correctly select the appropriate site for specimen collection used for both direct microscopy and fungal culture. Topical antifungal agents may be considered for the treatment of early onychomycosis, in the absence of nail matrix involvement. The newer generation of oral antifungal agents for the treatment of onychomycosis are terbinafine, itraconazole and fluconazole. These drugs used alone, or in combination with topical antifungals, are providing the basis for effective treatment of onychomycosis in a large proportion of patients.
甲癣是最常见的指甲疾病，约占所有皮肤真菌感染的30%。治疗方法需要考虑甲癣的部位和范围、药物对真菌的敏感性、不良反应情况、给药方案、治疗持续时间、伴随的疾病状况以及同时服用的药物。为确诊，正确选择用于直接显微镜检查和真菌培养的标本采集合适部位很重要。对于早期甲癣，在未累及甲母质的情况下，可考虑使用外用抗真菌药。治疗甲癣的新一代口服抗真菌药有特比萘芬、伊曲康唑和氟康唑。这些药物单独使用或与外用抗真菌药联合使用，为大部分患者有效治疗甲癣提供了依据。
