血管通透性因子与血管内皮生长因子在卵巢过度刺激综合征中的作用：初步报告
Vascular permeability factor and vascular endothelial growth factor in ovarian hyperstimulation syndrome: a preliminary report.
作者信息
Krasnow J S, Berga S L, Guzick D S, Zeleznik A J, Yeo K T
机构信息
Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA.
出版信息
Fertil Steril. 1996 Mar;65(3):552-5.
OBJECTIVE
To determine whether serum levels of vascular permeability factor (VPF) are elevated in patients with ovarian hyperstimulation syndrome (OHSS) and to determine if luteinizing granulosa cells may be a source of VPF.
DESIGN
Prospective observational study.
SETTING
University IVF and GIFT program.
PATIENTS
Eight consecutive IVF and GIFT patients at high risk for OHSS.
MAIN OUTCOME MEASURES
Vascular permeability factor concentration in serum and follicular fluid.
RESULTS
Serum VPF was significantly higher (15.2 +/- 4.0 pM; mean +/- SEM) on day +14 in the group who developed severe OHSS compared with those who did not. Follicular fluid VPF (171.5 +/- 18.5 pM) was approximately 100-fold greater than serum (1.7 +/- 1.3 pM) or peritoneal fluid (2.5 +/- 1.3 pM) 36 hours after hCG administration.
CONCLUSION
Vascular permeability factor is elevated in patients with severe OHSS and the ovary may be a source of VPF secretion.
目的
确定卵巢过度刺激综合征（OHSS）患者血清中血管通透性因子（VPF）水平是否升高，并确定黄素化颗粒细胞是否可能是VPF的来源。
设计
前瞻性观察研究。
地点
大学体外受精和配子输卵管内移植项目。
患者
连续8例有OHSS高风险的体外受精和配子输卵管内移植患者。
主要观察指标
血清和卵泡液中血管通透性因子浓度。
结果
与未发生严重OHSS的患者相比，发生严重OHSS的患者在第14天血清VPF显著更高（15.2±4.0皮摩尔；均值±标准误）。注射hCG 36小时后，卵泡液VPF（171.5±18.5皮摩尔）比血清（1.7±1.3皮摩尔）或腹腔液（2.5±1.3皮摩尔）高约100倍。
结论
严重OHSS患者血管通透性因子升高，卵巢可能是VPF分泌的来源。
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