Giorlandino C, Calugi G, Iaconianni L, Santoro M L, Lippa A
Sterility Department, Artemisia Medical Center, Rome, Italy.
Fertil Steril. 1998 Sep;70(3):576-7. doi: 10.1016/s0015-0282(98)00192-7.
To determine whether sperm aneuploidy can lead to abortion.
Clinical study.
Couples with reproductive problems evaluated in a private diagnostic laboratory.
PATIENT(S): Two men whose wives had histories of multiple abortions.
INTERVENTION(S): Whole and Percoll-processed semen samples were analyzed.
MAIN OUTCOME MEASURE(S): The results of fluorescence in situ hybridization.
RESULT(S): Aneuploidy rates in Percoll-processed samples were higher than those found in whole specimens. Aneuploid spermatozoa also displayed greater motility.
CONCLUSION(S): Sperm aneuploidy should be studied before and after Percoll capacitation in all couples with unexplained infertility.
确定精子非整倍体是否会导致流产。
临床研究。
在一家私人诊断实验室对有生殖问题的夫妇进行评估。
两名妻子有多次流产史的男性。
分析了未经处理和经Percoll处理的精液样本。
荧光原位杂交结果。
经Percoll处理的样本中的非整倍体率高于未经处理的样本。非整倍体精子也表现出更强的活力。
对于所有不明原因不孕的夫妇，都应在Percoll诱导获能前后研究精子非整倍体情况。
