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一项来自印度的成人强迫症的临床遗传学研究。

A clinical genetic study of adult obsessive compulsive disorder from India.

机构信息

R. GURUSWAMY, Consultant Psychiatrist, St. Jude's Hospital, V /Foil, St Lucia, P.O. Box 331, West Indies.

出版信息

Indian J Psychiatry. 2002 Jul;44(3):240-5.

PMID:21206578
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2954394/
Abstract

OBJECTIVE

The current study aims to replicate western reports of a familial excess of syndromal and sub-syndromal Obsessive Compulsive Disorder (OCD) in OCD probands in an Indian population.

METHOD

148 relatives of OCD probands were compared with 151 normal subjects, based on evaluation on Schedule for Clinical Assessment for Neuropsychiatry (SCAN).

RESULTS

There were no clinically significant differences in the prevalence of psychiatric disorders between the two samples.

CONCLUSION

In an Indian setting, the absence of familial loading in adult OCD is being reported. Whether subgroups of OCD are familial, or other factors play a role in the pathogenesis of OCD in India needs to be explored.

摘要

目的

本研究旨在复制西方报道,即在印度人群中,强迫症患者的综合征和亚综合征强迫症(OCD)家族性过度。

方法

根据精神障碍临床评估量表(SCAN)评估,将 148 名强迫症患者的亲属与 151 名正常受试者进行比较。

结果

两组样本的精神障碍患病率无临床显著差异。

结论

在印度环境中,报告称成年 OCD 不存在家族性负荷。在印度,OCD 的发病机制中是否存在亚组 OCD 家族性,或者其他因素起作用,需要进一步探讨。

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引用本文的文献

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本文引用的文献

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A family study of juvenile obsessive-compulsive disorder.青少年强迫症的家族研究。
Can J Psychiatry. 2001 May;46(4):346-51. doi: 10.1177/070674370104600406.
2
The relationship between obsessive-compulsive disorder and anxiety and affective disorders: results from the Johns Hopkins OCD Family Study.强迫症与焦虑症及情感障碍之间的关系:约翰·霍普金斯强迫症家族研究的结果
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Psychiatric disorders in first-degree relatives of children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS).患有与链球菌感染相关的小儿自身免疫性神经精神障碍(PANDAS)的儿童的一级亲属中的精神障碍
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Biol Psychiatry. 2000 Aug 15;48(4):287-93. doi: 10.1016/s0006-3223(00)00831-3.
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A family study of obsessive-compulsive disorder.强迫症的家族研究。
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