Perani D
Institute of Neuroscience and Bioimaging CNR, Milan, Italy.
C R Acad Sci III. 1998 Feb-Mar;321(2-3):199-205. doi: 10.1016/s0764-4469(97)89822-8.
The development of neuroimaging methods such as PET, has provided a new impulse to the study of the neural basis of cognitive functions, and has extended the field of inquiry from the analysis of the consequences of brain lesions to the functional investigations of brain activity, either in patients with selective neuropsychological deficits or in normal subjects engaged in cognitive tasks. Specific patterns of hypometabolism in neurological patients are associated with different profiles of memory deficits. [18F]FDG PET studies have confirmed the association of episodic memory with the structures of Papez's circuit and have shown correlations between short-term and semantic memory and the language areas. The identification of anatomo-functional networks involved in specific components of memory function in normal subjects is the aim of several PET activation studies. The results are in agreement with 'neural network' models of the neural basis of memory, as complex functions subserved by multiple interconnected cortical and subcortical structures.
正电子发射断层扫描（PET）等神经成像方法的发展，为认知功能神经基础的研究提供了新的推动力，并将研究领域从脑损伤后果分析扩展到对脑活动的功能研究，无论是对有选择性神经心理缺陷的患者，还是对从事认知任务的正常受试者。神经疾病患者特定的代谢减低模式与不同类型的记忆缺陷相关。[18F]氟代脱氧葡萄糖（FDG）PET研究证实了情景记忆与帕佩兹环路结构的关联，并显示了短期和语义记忆与语言区域之间的相关性。确定正常受试者记忆功能特定组成部分所涉及的解剖功能网络是多项PET激活研究的目标。研究结果与记忆神经基础的“神经网络”模型一致，即复杂功能由多个相互连接的皮质和皮质下结构共同承担。
