Van Regenmortel M H
Institut de Biologie Moléculaire et Cellulaire, CNRS 15, UPR 9021, Strasbourg, France.
J Immunol Methods. 1998 Jul 1;216(1-2):37-48. doi: 10.1016/s0022-1759(98)00069-6.
The term specificity is derived from the word species and shares with it an inherent fuzziness based on the absence of sharp boundaries between closely related entities. Antibody specificity is a ternary relational property which refers to the antibody's capacity to discriminate between two or more epitopes. There are no sharp boundaries between the individual overlapping epitopes that constitute an antigenic site and there is also no clear-cut minimum difference in binding affinity or in atomic positions at the epitope-paratope interface that can serve as a yardstick for deciding that two epitopes or two paratopes are the same or not. Immunology shares with the whole of empirical science the need to handle fuzzy sets and concepts and this poses no threat to the unabated further development of immunochemical analysis.
“特异性”一词源于“物种”一词，并且与之一样，由于密切相关的实体之间缺乏明确界限而具有内在的模糊性。抗体特异性是一种三元关系属性，它指的是抗体区分两个或更多表位的能力。构成抗原位点的各个重叠表位之间没有明确界限，并且在表位-互补位界面处的结合亲和力或原子位置上也没有明确的最小差异可作为判断两个表位或两个互补位是否相同的标准。免疫学与整个经验科学一样，需要处理模糊集和概念，而这对免疫化学分析的持续进一步发展并无威胁。
