Simmen D, Briner H R, Schär G, Schuknecht B
Klinik für Otorhinolaryngologie, Hals- und Gesichtschirurgie, Universitätsspital Zürich.
Laryngorhinootologie. 1998 Aug;77(8):444-53. doi: 10.1055/s-2007-997005.
Many host factors even in immunocompetent patients may have an influence on development of a fungal diseases within the paranasal sinuses. Fungal sinusitis can occur in an acute form or more often to a chronic type of the disease. These mainly relatively asymptomatic chronic forms and further divided into a chronic noninvasive, chronic allergic, and chronic invasive disease. Endonasal microsurgery has significantly changed the management of chronic fungal sinusitis and allows adequate removal of pathologic tissue even in advanced situations. The aim of this study was to analyze the efficacy of endonasal surgery in chronic fungal sinusitis.
In a retrospective study we assessed a group of 40 patients who had endonasal surgery for chronic fungal sinusitis. Patient records, CT and MRI scans, microbiology and histology as well as the postoperative clinical follow-up including endoscopic photo documentation were evaluated over a period of 5 years. All patients underwent endonasal surgery using endoscopic techniques. The microscopic was of additional help in a few cases with extended disease and multiple dehiscences of the skull base.
Twenty-four patients had a chronic noninvasive of fungal sinusitis and 16 patients had a chronic invasive form. All these patients underwent endonasal surgery without external incision. The fungal disease was erradicated in 39 cases, and revision surgery was required in only one case in which involvement of the contralateral side was not initially detected. in two cases scar tissue in the middle meatus was later excised but without evidence of residual fungal disease. Only in 6 cases was antifungal chemotherapy required, where the disease had spread into surrounding tissue or the patient had severe symptoms.
Endonasal microsurgical techniques are today the appropriate approach for managing chronic fungal sinus disease even in severe cases with radiologic evidence of expansion or invasion of surrounding tissue. Additional antifungal chemotherapy is only rarely indicated, specifically when the fungal disease invades surrounding tissue.
即使在免疫功能正常的患者中,许多宿主因素也可能影响鼻窦真菌病的发生。真菌性鼻窦炎可呈急性形式出现,但更常见的是慢性疾病类型。这些主要是相对无症状的慢性形式,进一步分为慢性非侵袭性、慢性变应性和慢性侵袭性疾病。鼻内显微手术显著改变了慢性真菌性鼻窦炎的治疗方式,即使在病情严重的情况下也能充分切除病变组织。本研究的目的是分析鼻内手术治疗慢性真菌性鼻窦炎的疗效。
在一项回顾性研究中,我们评估了一组40例行鼻内手术治疗慢性真菌性鼻窦炎的患者。对患者记录、CT和MRI扫描、微生物学和组织学以及术后临床随访(包括内镜照片记录)进行了为期5年的评估。所有患者均采用内镜技术进行鼻内手术。在少数病变范围广泛且颅底多处裂开的病例中,显微镜检查有额外帮助。
24例患者为慢性非侵袭性真菌性鼻窦炎,16例为慢性侵袭性类型。所有这些患者均未行外部切口进行鼻内手术。39例患者的真菌病得到根除,仅1例因最初未发现对侧受累而需要再次手术。2例患者中鼻道的瘢痕组织后来被切除,但无残留真菌病证据。仅6例患者需要抗真菌化疗,这些患者的疾病已扩散至周围组织或患者有严重症状。
如今,鼻内显微手术技术是治疗慢性真菌性鼻窦疾病的合适方法,即使在有影像学证据显示周围组织扩张或侵袭的严重病例中也是如此。仅在极少数情况下需要额外的抗真菌化疗,特别是当真菌病侵袭周围组织时。