Zielonka T M, Demkow U, Kowalski J, Kuś J, Krychniak-Soszka A, Radzikowska E, Skopińska-Rózewska E, Rowińska-Zakrzewska E
Zakładu Fizjopatologii, Instytutu Gruźlicy i Chorób Płuc w Warszawie.
Pneumonol Alergol Pol. 1997;65(11-12):754-60.
Angiogenesis is a process of new blood vessels' formation occurring in many physiological and pathological conditions. Neovascularisation is the principal vascular response in chronic inflammation and concomitant fibrotic process. Microvascular changes in various organ sites in sarcoidosis (BBS) and some of the symptoms of the disease may be related to microangiopathy. Moreover, vascular alterations were also observed in lung specimens from idiopathic pulmonary fibrosis (IPF) and avian fanciers lung (AFL) patients. The present study was aimed at testing the effects of serum from 43 patients with ILD (24 BBS, 8 AFL, 8 IPF, 3 DIPF--drug induced pulmonary fibrosis) and 11 healthy controls on angiogenic capability of normal blood peripheral mononuclear cells (PBMC) in the murine intradermal angiogenesis assay (according to Sidky and Auerbach). The data demonstrated that sera from ILD patients significantly enhanced angiogenic capacity of normal PBMC as compared to control sera (p < 0.001). The effect was more pronounced for AFL patients than for BBS and IPF ones (p < 0.05). Sera from DIPF did not stimulate angiogenesis compared to control sera. The data showed that sera from ILD patients constitute sources of mediators participating in angiogenesis. This phenomenon may play role in pathogenesis of chronic immunological processes in lung.
血管生成是一个在许多生理和病理条件下发生的新血管形成过程。新生血管形成是慢性炎症和伴随的纤维化过程中的主要血管反应。结节病（BBS）中各个器官部位的微血管变化以及该疾病的一些症状可能与微血管病变有关。此外，在特发性肺纤维化（IPF）和养鸟人肺（AFL）患者的肺标本中也观察到了血管改变。本研究旨在通过小鼠皮内血管生成试验（根据Sidky和Auerbach的方法），检测43例ILD患者（24例BBS、8例AFL、8例IPF、3例DIPF——药物性肺纤维化）和11例健康对照者的血清对正常外周血单个核细胞（PBMC）血管生成能力的影响。数据表明，与对照血清相比，ILD患者的血清显著增强了正常PBMC的血管生成能力（p < 0.001）。AFL患者的这种作用比BBS和IPF患者更明显（p < 0.05）。与对照血清相比，DIPF患者的血清未刺激血管生成。数据显示，ILD患者的血清构成了参与血管生成的介质来源。这种现象可能在肺部慢性免疫过程的发病机制中起作用。
