Department of Family Medicine, Warsaw Medical University, Warsaw, Poland.
Eur J Med Res. 2010 Nov 4;15 Suppl 2(Suppl 2):229-34. doi: 10.1186/2047-783x-15-s2-229.
Chronic inflammation and fibrosis are characteristic of interstitial lung diseases (ILD) and are accompanied by neovascularisation. The aim of this study was to examine the relationship between the angiogenic activity of sera from ILD patients and pulmonary function tests.
Serum samples were obtained from 225 ILD patients: 83 with sarcoidosis, 31 with idiopathic pulmonary fibrosis, 29 with extrinsic allergic alveolitis, 16 with collagen vascular diseases, 13 with scleroderma with pulmonary manifestations (SCL), 14 with Wegener's granulomatosis (WG), 12 with silicosis, 12 with pulmonary Langerhans cells histiocytosis, 10 with drug-induced pulmonary fibrosis, 5 with cryptogenic organizing pneumonia, and 36 healthy volunteers. An animal model of leukocyte induced angiogenesis assay was used as an angiogenic test. In all patients spirometry, whole body plethysmography, static lung compliance, and single breath diffusing capacity of the lungs for carbon monoxide (DLco) were performed.
The angiogenic properties of sera from ILD differed, depending on the disease. In the examined ILD, the most important functional disturbances were decreases in static compliance and DLco. The correlation between DLco and angiogenic activity of sera was observed (P<0.05).
The data show that sera from ILD patients constitute a source of mediators modulating angiogenesis. Angiogenic activity of sera of ILD patients is related to DLco.
慢性炎症和纤维化是间质性肺疾病（ILD）的特征，伴有新生血管形成。本研究旨在探讨ILD 患者血清的血管生成活性与肺功能测试之间的关系。
从 225 名ILD 患者中获得血清样本：83 名结节病患者，31 名特发性肺纤维化患者，29 名外源性过敏性肺泡炎患者，16 名胶原血管疾病患者，13 名有肺部表现的硬皮病患者（SCL），14 名韦格纳肉芽肿（WG）患者，12 名矽肺患者，12 名肺朗格汉斯细胞组织细胞增生症患者，10 名药物性肺纤维化患者，5 名隐源性机化性肺炎患者，36 名健康志愿者。使用白细胞诱导的血管生成测定作为血管生成试验。在所有患者中进行了肺量计检查、全身体积描记法、静态肺顺应性和一氧化碳单呼吸弥散量（DLco）。
ILD 患者血清的血管生成特性因疾病而异。在所检查的ILD 中，最重要的功能障碍是静态顺应性和 DLco 的降低。观察到 DLco 与血清血管生成活性之间存在相关性（P<0.05）。
数据表明，ILD 患者的血清构成了调节血管生成的介质来源。ILD 患者血清的血管生成活性与 DLco 相关。
