Vine W, Smith P, LaChappell R, Blase E, Young A
Amylin Pharmaceuticals Inc., San Diego, CA 92121, USA.
Horm Metab Res. 1998 Aug;30(8):518-22. doi: 10.1055/s-2007-978924.
Amylin is a peptide secreted from the pancreatic beta-cell along with insulin in response to nutrient stimuli. Amylin has been reported to delay gastric emptying, inhibit glucagon secretion and gastric acid secretion, increase plasma lactate, plasma glucose and plasma renin activity, and decrease plasma calcium. Receptors for amylin have been found in the rat nucleus accumbens and the kidney. In the present experiments, amylin was administered to anesthetized rats by continuous intravenous infusions at varied rates. Amylin significantly increased urine flow at an infusion rate resulting in a plasma concentration of approximately 52 pM, and at a concentration of approximately 193 pM, it increased sodium excretion, glomerular filtration rate and renal plasma flow. Renal calcium and potassium excretion were significantly elevated at plasma amylin concentrations of approximately 52 pM and 193 pM, respectively. Higher concentrations of plasma amylin decreased plasma calcium and potassium and blunted urinary excretion of these electrolytes. Thus, of the renal responses tested, diuresis and natriuresis appeared to be the most sensitive to infused amylin. These renal effects occurred only at plasma concentrations above the normal range, but within the range of concentrations reported in insulin resistant rats.
胰淀素是一种在营养刺激下与胰岛素一起从胰腺β细胞分泌的肽。据报道，胰淀素可延迟胃排空、抑制胰高血糖素分泌和胃酸分泌、增加血浆乳酸、血浆葡萄糖和血浆肾素活性，并降低血浆钙。在大鼠伏隔核和肾脏中发现了胰淀素受体。在本实验中，以不同速率通过连续静脉输注将胰淀素给予麻醉大鼠。在输注速率导致血浆浓度约为52 pM时，胰淀素显著增加尿流量，在浓度约为193 pM时，它增加钠排泄、肾小球滤过率和肾血浆流量。在血浆胰淀素浓度分别约为52 pM和193 pM时，肾钙和钾排泄显著升高。更高浓度的血浆胰淀素降低血浆钙和钾，并使这些电解质的尿排泄减弱。因此，在所测试的肾脏反应中，利尿和利钠似乎对输注的胰淀素最敏感。这些肾脏效应仅在血浆浓度高于正常范围时出现，但在胰岛素抵抗大鼠报道的浓度范围内。
