Dodd M A, Dole E J, Troutman W G, Bennahum D A
Presbyterian Healthcare Services, Albuquerque, NM, USA.
Ann Pharmacother. 1998 Sep;32(9):887-9. doi: 10.1345/aph.17397.
To describe a case of tooth discoloration in an adult after minocycline treatment for arthritis.
A 68-year-old white women presented with blue-black staining of her lower anterior teeth after 4 months of minocycline therapy for arthritis. Her other medications are not known to cause discoloration of teeth. While the patient continued taking minocycline, her dentist was not able to remove the discoloration. Within 1 month after discontinuation of the minocycline, the dentist was able to remove the discoloration entirely.
Minocycline, a synthetic derivative of tetracycline, has been shown to cause abnormal pigmentation of the skin, thyroid gland, nails, bone, sclera, and conjunctiva in adults. It also has been shown to cause tooth discoloration in a few patients. This case is unusual in that the tooth discoloration disappeared after discontinuing minocycline therapy.
This complication of minocycline is more commonly thought of in the pediatric population. However, clinicians need to be aware of this adverse drug reaction, as this agent may be used increasingly in the treatment of adults with arthritis.
描述1例成年患者在接受米诺环素治疗关节炎后出现牙齿变色的病例。
一名68岁白人女性，在接受米诺环素治疗关节炎4个月后，下前牙出现蓝黑色染色。已知其服用的其他药物不会导致牙齿变色。患者继续服用米诺环素期间，其牙医无法去除牙齿变色。停用米诺环素1个月内，牙医能够完全去除牙齿变色。
米诺环素是四环素的合成衍生物，已被证明可导致成人皮肤、甲状腺、指甲、骨骼、巩膜和结膜出现异常色素沉着。也有少数患者出现牙齿变色。该病例的不同寻常之处在于停用米诺环素治疗后牙齿变色消失。
米诺环素的这种并发症在儿科人群中更为常见。然而，临床医生需要意识到这种药物不良反应，因为该药物在成年关节炎患者治疗中的使用可能会越来越多。
