Fung W K, Chan H L, Lam W M
Department of Health, The Chinese University of Hong Kong.
Int J Dermatol. 1998 Sep;37(9):659-63. doi: 10.1046/j.1365-4362.1998.00453.x.
Amyopathic dermatomyositis (ADM) is a rare variant of dermatomyositis (DM) in which there is no apparent muscle involvement at initial presentation, but clinical and laboratory evidence of myopathy may appear later. Like DM, it has a known association with malignancy.
To record the occurrence of ADM in Hong Kong during the period from January 1988 to June 1996, and to establish the types of carcinoma with which it is associated.
The records of all patients diagnosed with ADM in three major dermatology clinics in Hong Kong were retrospectively studied to confirm the diagnosis and to look for any associated malignancy at any stage of the disease.
Between 1988 and 1996, six patients in Hong Kong (five men and one woman; mean age, 50 years) fulfilled the criteria of ADM. During a follow-up period ranging from 20 to 90 months (average, 35.6 months), none developed any evidence of myositis. Associated malignancy was found in the five male patients. There were three cases of nasopharyngeal carcinoma (NPC), one case of non-small cell carcinoma of the lung, and one case of metastatic carcinoma of the cervical lymph node of unknown primary. No carcinoma had developed in the female patient during a follow-up period of 90 months.
There is a strong association between ADM and NPC in Hong Kong.
无肌病性皮肌炎（ADM）是皮肌炎（DM）的一种罕见变异型，其在初发时无明显肌肉受累，但后期可能出现肌病的临床和实验室证据。与DM一样，它与恶性肿瘤有已知的关联。
记录1988年1月至1996年6月期间香港ADM的发病情况，并确定与之相关的癌症类型。
对香港三家主要皮肤科诊所诊断为ADM的所有患者的记录进行回顾性研究，以确认诊断并在疾病的任何阶段寻找任何相关的恶性肿瘤。
1988年至1996年期间，香港有6例患者（5名男性和1名女性；平均年龄50岁）符合ADM标准。在20至90个月（平均35.6个月）的随访期内，无人出现任何肌炎证据。5名男性患者发现有相关恶性肿瘤。有3例鼻咽癌（NPC）、1例非小细胞肺癌和1例原发灶不明的颈部淋巴结转移癌。在90个月的随访期内，女性患者未发生癌症。
在香港，ADM与NPC之间存在密切关联。
